Repurposing of promoters and enhancers during mammalian evolution.

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State: Public
Version: Final published version
Serval ID
serval:BIB_B849DBF5E53D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Repurposing of promoters and enhancers during mammalian evolution.
Journal
Nature communications
Author(s)
Carelli F.N., Liechti A., Halbert J., Warnefors M., Kaessmann H.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Publication state
Published
Issued date
04/10/2018
Peer-reviewed
Oui
Volume
9
Number
1
Pages
4066
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Promoters and enhancers-key controllers of gene expression-have long been distinguished from each other based on their function. However, recent work suggested that common architectural and functional features might have facilitated the conversion of one type of element into the other during evolution. Here, based on cross-mammalian analyses of epigenome and transcriptome data, we provide support for this hypothesis by detecting 445 regulatory elements with signatures of activity turnover (termed P/E elements). Most events represent transformations of putative ancestral enhancers into promoters, leading to the emergence of species-specific transcribed loci or 5' exons. Distinct GC sequence compositions and stabilizing 5' splicing (U1) regulatory motif patterns may have predisposed P/E elements to regulatory repurposing, and changes in the U1 and polyadenylation signal densities and distributions likely drove the evolutionary activity switches. Our work suggests that regulatory repurposing facilitated regulatory innovation and the origination of new genes and exons during evolution.
Keywords
Animals, Enhancer Elements, Genetic, Evolution, Molecular, Primates/genetics, Promoter Regions, Genetic, Rodentia/genetics
Pubmed
Web of science
Open Access
Yes
Create date
12/10/2018 9:01
Last modification date
20/08/2019 15:26
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