Microbial influences on epithelial integrity and immune function as a basis for inflammatory diseases.

Details

Serval ID
serval:BIB_B8259105FE97
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Microbial influences on epithelial integrity and immune function as a basis for inflammatory diseases.
Journal
Immunological Reviews
Author(s)
Macia L., Thorburn A.N., Binge L.C., Marino E., Rogers K.E., Maslowski K.M., Vieira A.T., Kranich J., Mackay C.R.
ISSN
1600-065X (Electronic)
ISSN-L
0105-2896
Publication state
Published
Issued date
2012
Volume
245
Number
1
Pages
164-176
Language
english
Abstract
Certain autoimmune diseases as well as asthma have increased in recent decades, particularly in developed countries. The hygiene hypothesis has been the prevailing model to account for this increase; however, epidemiology studies also support the contribution of diet and obesity to inflammatory diseases. Diet affects the composition of the gut microbiota, and recent studies have identified various molecules and mechanisms that connect diet, the gut microbiota, and immune responses. Herein, we discuss the effects of microbial metabolites, such as short chain fatty acids, on epithelial integrity as well as immune cell function. We propose that dysbiosis contributes to compromised epithelial integrity and disrupted immune tolerance. In addition, dietary molecules affect the function of immune cells directly, particularly through lipid G-protein coupled receptors such as GPR43.
Keywords
Animals, Bacteria/immunology, Bacteria/metabolism, Bacterial Infections/complications, Bacterial Infections/immunology, Diet, Dietary Supplements, Fatty Acids/immunology, Fatty Acids/metabolism, Humans, Immune System Diseases/etiology, Immune System Diseases/immunology, Immune Tolerance, Inflammation/immunology, Inflammation/microbiology, Intestinal Mucosa/immunology, Intestinal Mucosa/metabolism, Receptors, G-Protein-Coupled/metabolism
Pubmed
Web of science
Create date
07/12/2012 10:22
Last modification date
20/08/2019 15:26
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