[Blocking effect of anisodamine on acetylcholine receptor channels].

Details

Serval ID
serval:BIB_B821BAD8BAB3
Type
Article: article from journal or magazin.
Collection
Publications
Title
[Blocking effect of anisodamine on acetylcholine receptor channels].
Journal
Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica
Author(s)
Zhao C.L., Ron S., Liu C.G., He X.P., Xie Z.P.
ISSN
0253-9756 (Print)
ISSN-L
0253-9756
Publication state
Published
Issued date
1993
Peer-reviewed
Oui
Volume
14
Number
2
Pages
190-192
Language
english
Notes
Publication types: English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Abstract
Anisodamine, an analog of atropine, was isolated first in China. Patch-clamp technique was used to study the inhibitory effect of anisodamine (Ani) on acetylcholine receptor on the membrane of muscle innervated by neuron. Neural tube in embryo of Xenopus laevis were cultured. By whole-cell clamp and outside-out patch, we found that the inhibitory effect of Ani was obvious on both miniature end-plate currents (MEPC) and single channel. This effect was reversible and the minimal concentration for complete inhibition was 60 mumol.L-1, vs 1 and 0.5 mmol.L-1 for atropine and scopolamine, respectively. Our results indicate that Ani blocks both M-ACh and N-ACh receptors.
Keywords
Animals, Atropine/pharmacology, Cells, Cultured, Electrophysiology, Embryo, Nonmammalian, Motor Endplate/physiology, Receptors, Muscarinic/drug effects, Receptors, Nicotinic/drug effects, Scopolamine Hydrobromide/pharmacology, Solanaceous Alkaloids/pharmacology, Xenopus laevis
Pubmed
Create date
29/10/2013 11:11
Last modification date
20/08/2019 15:26
Usage data