Modulatory role of testosterone in plasma leptin turnover in rats

Details

Serval ID
serval:BIB_B7E0B3F59A32
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Modulatory role of testosterone in plasma leptin turnover in rats
Journal
Endocrine
Author(s)
Castrogiovanni  D., Perello  M., Gaillard  R. C., Spinedi  E.
ISSN
0969-711X (Print)
Publication state
Published
Issued date
12/2003
Volume
22
Number
3
Pages
203-10
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Dec
Abstract
We explored whether testosterone influences circulating leptin turnover in rats. Sham-operated male and female rats and 21-d gonadectomized rats treated or not treated with testosterone propionate were used. Anesthetized rats were implanted with an iv catheter, and then blood samples were drawn before and throughout a 60-min period following systemic leptin administration. Plasma testosterone, estradiol, and leptin concentrations were monitored. The results indicated that while gonadectomy blunted circulating concentrations of the homologous sex steroid, testosterone therapy, in gonadectomized rats, restored plasma testosterone concentrations to values found in normal male rats. Pharmacokinetic parameters evaluated during the test indicated the following: First, in the overall pharmacokinetic analyses, testosterone therapy in gonadectomized rats induced a more rapid disappearance of leptin from the circulation. Second, orchidectomy significantly enhanced the area under the curve (AUC) of circulating leptin, an effect fully reversed by testosterone treatment. Third, testosterone treatment in ovariectomized rats significantly decreased the AUC of leptin concentrations. Fourth, while gonadectomy alone did not modify circulating leptin half-life, conversely, testosterone therapy in gonadectomized rats decreased leptin halflife in the circulation. Finally, while orchidectomy reduced leptin body clearance, this parameter was increased by androgen therapy in gonadectomized rats. Our results strongly support that testosterone could play a main role in plasma leptin turnover by increasing leptin clearance rate and shortening plasma leptin half-life.
Keywords
Animals Area Under Curve Estradiol/blood Female Half-Life Least-Squares Analysis Leptin/*blood/*pharmacokinetics Male Multivariate Analysis Orchiectomy Ovariectomy Rats Rats, Wistar Sex Factors Testosterone/blood/*pharmacology
Pubmed
Web of science
Create date
15/02/2008 16:57
Last modification date
20/08/2019 15:25
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