Cutaneous Manifestations of Small-Vessel Leukocytoclastic Vasculitides in Childhood.
Details
Serval ID
serval:BIB_B7AD4BFAC78B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Cutaneous Manifestations of Small-Vessel Leukocytoclastic Vasculitides in Childhood.
Journal
Clinical reviews in allergy & immunology
ISSN
1559-0267 (Electronic)
ISSN-L
1080-0549
Publication state
Published
Issued date
12/2017
Peer-reviewed
Oui
Volume
53
Number
3
Pages
439-451
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Publication Status: ppublish
Abstract
In childhood, cutaneous small-vessel vasculitides include Henoch-Schönlein syndrome, a systemic vasculitis, and Finkelstein-Seidlmayer syndrome, a skin-limited vasculitis. Both Henoch-Schönlein and Finkelstein-Seidlmayer syndromes are seen more frequently in white or Asian compared with black children and occur especially in winter and spring with a male-to-female ratio of approximately 2:1. In everyday clinical practice, both conditions are diagnosed on clinical grounds without histological confirmation. The characteristic cutaneous hallmarks of Henoch-Schönlein syndrome include a purpuric rash in all and a subcutaneous edema in approximately every second case, which are often preceded by non-specific red or pink macular elements that mimic a non-itching urticarial rash. Recent data point out that Henoch-Schönlein children often present further cutaneous findings such as Köbnerization, Rumpel-Leede capillary fragility phenomenon, and blistering eruptions. Children with Finkelstein-Seidlmayer syndrome are usually ≤24 months of age and not ill-appearing. They present with (a) large, round, red to purpuric plaques (often with a targetoid appearance) predominantly over the cheeks, ears, and extremities and (b) often tender non-pitting edema of the distal extremities, ears, and face (without pruritus). Both in Henoch-Schönlein syndrome and Finkelstein-Seidlmayer syndrome, there is often scrotal involvement. The cutaneous findings remit without sequelae within 2 months in Henoch-Schönlein and 3 weeks in Finkelstein-Seidlmayer syndrome.
Keywords
Blood Vessels/pathology, Child, Edema, Exanthema, Humans, IgA Vasculitis, Male, Scrotum/pathology, Skin/immunology, Skin/pathology, Vasculitis, Leukocytoclastic, Cutaneous/immunology, Acute hemorrhagic edema, Anaphylactoid purpura, Cockade purpura and edema of young children, Finkelstein–Seidlmayer syndrome, Henoch–Schönlein syndrome
Pubmed
Web of science
Create date
10/03/2025 21:52
Last modification date
11/03/2025 11:08