Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention.

Details

Serval ID
serval:BIB_B7AD437C6019
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention.
Journal
Nature genetics
Author(s)
Wang Z., Emmerich A., Pillon N.J., Moore T., Hemerich D., Cornelis M.C., Mazzaferro E., Broos S., Ahluwalia T.S., Bartz T.M., Bentley A.R., Bielak L.F., Chong M., Chu A.Y., Berry D., Dorajoo R., Dueker N.D., Kasbohm E., Feenstra B., Feitosa M.F., Gieger C., Graff M., Hall L.M., Haller T., Hartwig F.P., Hillis D.A., Huikari V., Heard-Costa N., Holzapfel C., Jackson A.U., Johansson Å., Jørgensen A.M., Kaakinen M.A., Karlsson R., Kerr K.F., Kim B., Koolhaas C.M., Kutalik Z., Lagou V., Lind P.A., Lorentzon M., Lyytikäinen L.P., Mangino M., Metzendorf C., Monroe K.R., Pacolet A., Pérusse L., Pool R., Richmond R.C., Rivera N.V., Robiou-du-Pont S., Schraut K.E., Schulz C.A., Stringham H.M., Tanaka T., Teumer A., Turman C., van der Most P.J., Vanmunster M., van Rooij FJA, van Vliet-Ostaptchouk J.V., Zhang X., Zhao J.H., Zhao W., Balkhiyarova Z., Balslev-Harder M.N., Baumeister S.E., Beilby J., Blangero J., Boomsma D.I., Brage S., Braund P.S., Brody J.A., Bruinenberg M., Ekelund U., Liu C.T., Cole J.W., Collins F.S., Cupples L.A., Esko T., Enroth S., Faul J.D., Fernandez-Rhodes L., Fohner A.E., Franco O.H., Galesloot T.E., Gordon S.D., Grarup N., Hartman C.A., Heiss G., Hui J., Illig T., Jago R., James A., Joshi P.K., Jung T., Kähönen M., Kilpeläinen T.O., Koh W.P., Kolcic I., Kraft P.P., Kuusisto J., Launer L.J., Li A., Linneberg A., Luan J., Vidal P.M., Medland S.E., Milaneschi Y., Moscati A., Musk B., Nelson C.P., Nolte I.M., Pedersen N.L., Peters A., Peyser P.A., Power C., Raitakari O.T., Reedik M., Reiner A.P., Ridker P.M., Rudan I., Ryan K., Sarzynski M.A., Scott L.J., Scott R.A., Sidney S., Siggeirsdottir K., Smith A.V., Smith J.A., Sonestedt E., Strøm M., Tai E.S., Teo K.K., Thorand B., Tönjes A., Tremblay A., Uitterlinden A.G., Vangipurapu J., van Schoor N., Völker U., Willemsen G., Williams K., Wong Q., Xu H., Young K.L., Yuan J.M., Zillikens M.C., Zonderman A.B., Ameur A., Bandinelli S., Bis J.C., Boehnke M., Bouchard C., Chasman D.I., Smith G.D., de Geus EJC, Deldicque L., Dörr M., Evans M.K., Ferrucci L., Fornage M., Fox C., Garland T., Gudnason V., Gyllensten U., Hansen T., Hayward C., Horta B.L., Hyppönen E., Jarvelin M.R., Johnson W.C., Kardia SLR, Kiemeney L.A., Laakso M., Langenberg C., Lehtimäki T., Marchand L.L., Magnusson PKE, Martin N.G., Melbye M., Metspalu A., Meyre D., North K.E., Ohlsson C., Oldehinkel A.J., Orho-Melander M., Pare G., Park T., Pedersen O., Penninx BWJH, Pers T.H., Polasek O., Prokopenko I., Rotimi C.N., Samani N.J., Sim X., Snieder H., Sørensen TIA, Spector T.D., Timpson N.J., van Dam R.M., van der Velde N., van Duijn C.M., Vollenweider P., Völzke H., Voortman T., Waeber G., Wareham N.J., Weir D.R., Wichmann H.E., Wilson J.F., Hevener A.L., Krook A., Zierath J.R., Thomis MAI, Loos RJF, Hoed M.D.
Working group(s)
Lifelines Cohort Study
Contributor(s)
Alizadeh B.Z., Boezen H.M., Franke L., Swertz M., Wijmenga C., van der Harst P., Navis G., Rots M., Wolffenbuttel BHR
ISSN
1546-1718 (Electronic)
ISSN-L
1061-4036
Publication state
In Press
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry meta-analysis of genome-wide association studies yields 99 loci that associate with self-reported moderate-to-vigorous intensity physical activity during leisure time (MVPA), leisure screen time (LST) and/or sedentary behavior at work. Loci associated with LST are enriched for genes whose expression in skeletal muscle is altered by resistance training. A missense variant in ACTN3 makes the alpha-actinin-3 filaments more flexible, resulting in lower maximal force in isolated type II <sub>A</sub> muscle fibers, and possibly protection from exercise-induced muscle damage. Finally, Mendelian randomization analyses show that beneficial effects of lower LST and higher MVPA on several risk factors and diseases are mediated or confounded by body mass index (BMI). Our results provide insights into physical activity mechanisms and its role in disease prevention.
Pubmed
Open Access
Yes
Create date
13/09/2022 9:29
Last modification date
16/09/2022 6:37
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