Biphasic response of a tecto-mesencephalic pilocytic astrocytoma after Gamma Knife surgery - A case report.

Details

Serval ID
serval:BIB_B7AB63484663
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Biphasic response of a tecto-mesencephalic pilocytic astrocytoma after Gamma Knife surgery - A case report.
Journal
Neurochirurgie
Author(s)
Tuleasca C., Negretti L., Magaddino V., Maeder P., Lhermitte B., Borruat F.X., Levivier M.
ISSN
0028-3770 (Print)
ISSN-L
0028-3770
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
61
Number
4
Pages
275-278
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
Biphasic response (shrinkage-regrowth-shrinkage) of tumors has never previously been reported in the postoperative course, neither after microsurgery, nor after Gamma Knife surgery (GKS). We present the case of an adult with dorsal midbrain syndrome resulting from a pilocytic astrocytoma centered on the mesencephalic tectum. The tumor extended to the third ventricle and the thalamus. Initially, due to tumor growth, a biopsy was performed and histology established. Later, a ventriculocisternostomy for obstructive hydrocephalus was performed. Finally, GKS was performed, as the tumor continued to grow. After GKS, the lesion exhibited a biphasic response, with a major shrinkage at 3 months, regrowth within the target volume at 6 and 9 months and a second phase of important shrinkage at 12 months, which persisted for the next two years. The possible mechanisms for this particular response pattern are discussed.
Pubmed
Web of science
Create date
16/06/2015 16:16
Last modification date
20/08/2019 15:25
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