Elastic behaviour of the carotid artery in intact spontaneously hypertensive rats

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Serval ID
serval:BIB_B7A4734A17B4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Elastic behaviour of the carotid artery in intact spontaneously hypertensive rats
Journal
European Heart Journal
Author(s)
Hayoz D., Rutschmann B., Genton C. Y., Niederberger M., Brunner H. R., Waeber B.
ISSN
0195-668X (Print)
Publication state
Published
Issued date
07/1993
Volume
14 Suppl C
Pages
10-3
Language
english
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jul
Abstract
Intact spontaneously hypertensive rats (SHR) were studied to assess the effect of prolonged antihypertensive treatment on the elastic behaviour of the external carotid artery. Thirty-week-old SHR received the ACE inhibitor captopril, the arteriolar dilator hydralazine or their vehicle for 6 weeks. These rats were compared to normotensive, vehicle treated WKY rats. The internal diameter of the carotid artery was measured continuously in halothane-anaesthetized rats using an echo-tracking device, and intra-arterial pressure was also monitored continuously, on the contralateral side. Captopril- and hydralazine-treated SHR as well as normotensive controls had similar blood pressure values. No significant shift in the distensibility-pressure curves was observed among vehicle-treated SHR and WKY rats or the SHR which had received captopril or hydralazine. Histological examination of the carotid artery fixed ex vivo with paraformaldehyde showed a significant increase in cross-sectional area in vehicle-treated SHR as compared to their normotensive counterparts. These results therefore suggest that the elastic behaviour of elastic arteries is not necessarily altered by the structural changes developing in response to hypertension.
Keywords
Animals Captopril/pharmacology Carotid Artery, External/drug effects/pathology/*physiopathology Compliance/drug effects Hydralazine/pharmacology Hypertension/pathology/*physiopathology Male Rats Rats, Inbred SHR Rats, Inbred WKY Vasodilator Agents/pharmacology
Pubmed
Web of science
Open Access
Yes
Create date
17/01/2008 16:38
Last modification date
01/10/2019 6:19
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