Cloning and characterization of TNKL, a member of tankyrase gene family.

Details

Serval ID
serval:BIB_B79C9E4690B6
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Cloning and characterization of TNKL, a member of tankyrase gene family.
Journal
Genes and Immunity
Author(s)
Kuimov A.N., Kuprash D.V., Petrov V.N., Vdovichenko K.K., Scanlan M.J., Jongeneel C.V., Lagarkova M.A., Nedospasov S.A.
ISSN
1466-4879[print], 1466-4879[linking]
Publication state
Published
Issued date
2001
Volume
2
Number
1
Pages
52-55
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
By serological screening of a breast tumor cDNA library we have identified a novel human gene, tnkl, encoding an ankyrin-related protein with a high degree of similarity to tankyrase, the poly(ADP-ribose)polymerase associated with human telomeres (Smith et al, Science 282: 1484). The tnkl gene maps to chromosome 10, while the tnks gene encoding tankyrase is located on chromosome 8. The predicted 1166-aa protein product of the tnkl gene is 78% identical to human tankyrase and 62% to a putative D. melanogaster protein. Since the proteins have essentially identical domain structures, the corresponding genes form a distinct gene family. The possible link between TNKL and cancer justifies its further functional analysis.
Keywords
Amino Acid Sequence, Animals, Base Sequence, Cloning, Molecular, DNA Primers, DNA, Complementary, Humans, Molecular Sequence Data, Poly(ADP-ribose) Polymerases/chemistry, Poly(ADP-ribose) Polymerases/genetics, Sequence Homology, Amino Acid, Tankyrases
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 15:39
Last modification date
20/08/2019 15:25
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