Does renal failure induce a decrease in cyclosporine blood concentrations?

Details

Serval ID
serval:BIB_B742741C535E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Does renal failure induce a decrease in cyclosporine blood concentrations?
Journal
Proceedings of the European Dialysis and Transplant Association - European Renal Association
Author(s)
Burnier  M., Aebischer  P., Wauters  J. P., Schelling  J. L.
ISSN
0931-0509
0308-9401 (Print)
Publication state
Published
Issued date
1985
Volume
21
Pages
1002-5
Notes
Comparative Study
Journal Article
Abstract
Blood Cys concentrations were monitored twice weekly by RIA in nine patients undergoing renal transplantation. The Cys dose was adapted to obtain blood values between 100-400ng/ml. A negative correlation was found between plasma creatinine and blood Cys, even in those patients in whom the oral dosage was not changed (r = 0.65, n = 23, p less than 0.001). In vitro studies showed no effect of uraemic blood on Cys measurement. It seems probable that uraemia induces changes in distribution volume and/or gastrointestinal absorption of the drug. Careful monitoring of Cys during uraemia is therefore warranted.
Keywords
Adult Cyclosporins/adverse effects/*blood Female Humans Kidney/drug effects Kidney Transplantation Male Middle Aged Uremia/*blood
Pubmed
Web of science
Create date
25/01/2008 12:56
Last modification date
20/08/2019 15:25
Usage data