An original valveless artificial heart providing pulsatile flow tested in mock circulatory loops.

Details

Serval ID
serval:BIB_B73B0B254132
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
An original valveless artificial heart providing pulsatile flow tested in mock circulatory loops.
Journal
The International journal of artificial organs
Author(s)
Tozzi P., Maertens A., Emery J., Joseph S., Kirsch M., Avellan F.
ISSN
1724-6040 (Electronic)
ISSN-L
0391-3988
Publication state
Published
Issued date
24/11/2017
Peer-reviewed
Oui
Volume
40
Number
12
Pages
683-689
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
We present the test bench results of a valveless total artificial heart that is potentially compatible with the pediatric population.
The RollingHeart is a valveless volumetric pump generating pulsatile flow. It consists of a single spherical cavity divided into 4 chambers by 2 rotating disks. The combined rotations of both disks produce changes in the volumes of the 4 cavities (suction and ejection). The blood enters/exits the spherical cavity through 4 openings that are symmetrical to the fixed rotation axis of the first disk.Mock circulatory system: The device pumps a 37% glycerin solution through 2 parallel circuits, simulating the pulmonary and systemic circulations. Flow rates are acquired with a magnetic inductive flowmeter, while pressure sensors collect pressure in the left and right outflow and inflow tracts.In vitro test protocol: The pump is run at speeds ranging from 20 to 180 ejections per minute. The waveform of the pressure generated at the inflow and outflow of the 4 chambers and the flow rate in the systemic circulation are measured.
At an ejection rate of 178 min-1, the RollingHeart pumps 5.3 L/min for a systemic maximal pressure gradient of 174 mmHg and a pulmonary maximal pressure gradient of 75 mmHg. The power input was 14 W, corresponding to an efficiency of 21%.
The RollingHeart represents a new approach in the domain of total artificial heart. This preliminary study endorses the feasibility of a single valveless device acting as a total artificial heart.
Keywords
Blood Circulation, Cardiovascular System/physiopathology, Heart Failure/physiopathology, Heart Failure/therapy, Heart Transplantation/instrumentation, Heart Transplantation/methods, Heart, Artificial, Humans, Mechanical Phenomena, Pulsatile Flow
Pubmed
Web of science
Create date
22/09/2017 13:56
Last modification date
20/08/2019 16:25
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