Programmed cell death: NINJ1 and mechanisms of plasma membrane rupture.

Details

Serval ID
serval:BIB_B7387FE546AF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Programmed cell death: NINJ1 and mechanisms of plasma membrane rupture.
Journal
Trends in biochemical sciences
Author(s)
Ramos S., Hartenian E., Broz P.
ISSN
0968-0004 (Print)
ISSN-L
0968-0004
Publication state
Published
Issued date
08/2024
Peer-reviewed
Oui
Volume
49
Number
8
Pages
717-728
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Lytic cell death culminates in cell swelling and plasma membrane rupture (PMR). The cellular contents released, including proteins, metabolites, and nucleic acids, can act as danger signals and induce inflammation. During regulated cell death (RCD), lysis is actively initiated and can be preceded by an initial loss of membrane integrity caused by pore-forming proteins, allowing small molecules and cytokines to exit the cell. A recent seminal discovery showed that ninjurin1 (NINJ1) is the common executioner of PMR downstream of RCD, resulting in the release of large proinflammatory molecules and representing a novel target of cell death-associated lysis. We summarize recent developments in understanding membrane integrity and rupture of the plasma membrane with a focus on NINJ1.
Keywords
Humans, Cell Membrane/metabolism, Cell Adhesion Molecules, Neuronal/metabolism, Animals, Nerve Growth Factors/metabolism, Apoptosis, NINJ1, apoptosis, damage-associated molecular patterns (DAMPs), inflammation, plasma membrane permeabilization, pyroptosis
Pubmed
Create date
28/06/2024 12:27
Last modification date
20/08/2024 7:23
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