A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_B72ACD5C7383
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal.
Journal
Modern pathology
Author(s)
Rindi G., Klimstra D.S., Abedi-Ardekani B., Asa S.L., Bosman F.T., Brambilla E., Busam K.J., de Krijger R.R., Dietel M., El-Naggar A.K., Fernandez-Cuesta L., Klöppel G., McCluggage W.G., Moch H., Ohgaki H., Rakha E.A., Reed N.S., Rous B.A., Sasano H., Scarpa A., Scoazec J.Y., Travis W.D., Tallini G., Trouillas J., van Krieken J.H., Cree I.A.
ISSN
1530-0285 (Electronic)
ISSN-L
0893-3952
Publication state
Published
Issued date
12/2018
Peer-reviewed
Oui
Volume
31
Number
12
Pages
1770-1786
Language
english
Notes
Publication types: Consensus Development Conference ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
The classification of neuroendocrine neoplasms (NENs) differs between organ systems and currently causes considerable confusion. A uniform classification framework for NENs at any anatomical location may reduce inconsistencies and contradictions among the various systems currently in use. The classification suggested here is intended to allow pathologists and clinicians to manage their patients with NENs consistently, while acknowledging organ-specific differences in classification criteria, tumor biology, and prognostic factors. The classification suggested is based on a consensus conference held at the International Agency for Research on Cancer (IARC) in November 2017 and subsequent discussion with additional experts. The key feature of the new classification is a distinction between differentiated neuroendocrine tumors (NETs), also designated carcinoid tumors in some systems, and poorly differentiated NECs, as they both share common expression of neuroendocrine markers. This dichotomous morphological subdivision into NETs and NECs is supported by genetic evidence at specific anatomic sites as well as clinical, epidemiologic, histologic, and prognostic differences. In many organ systems, NETs are graded as G1, G2, or G3 based on mitotic count and/or Ki-67 labeling index, and/or the presence of necrosis; NECs are considered high grade by definition. We believe this conceptual approach can form the basis for the next generation of NEN classifications and will allow more consistent taxonomy to understand how neoplasms from different organ systems inter-relate clinically and genetically.
Keywords
Humans, International Agencies, Neuroendocrine Tumors/classification, World Health Organization
Pubmed
Web of science
Open Access
Yes
Create date
04/09/2018 11:57
Last modification date
18/09/2019 6:10
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