Genetic variation near CXCL12 is associated with susceptibility to HIV-related non-Hodgkin lymphoma

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Serval ID
serval:BIB_B72746EA3CA7
Type
Autre: use this type when nothing else fits.
Collection
Publications
Institution
Title
Genetic variation near CXCL12 is associated with susceptibility to HIV-related non-Hodgkin lymphoma
Author(s)
Thorball Christian W., Oudot-Mellakh Tiphaine, Hammer Christian, Santoni Federico A., Niay Jonathan, Costagliola Dominique, Goujard Cécile, Meyer Laurence, Wang Sophia S., Hussain Shehnaz K., Theodorou Ioannis, Cavassini Matthias, Rauch Andri, Battegay Manuel, Hoffmann Matthias, Schmid Patrick, Bernasconi Enos, Günthard Huldrych F., McLaren Paul J., Rabkin Charles S., Besson Caroline, Fellay Jacques
ISSN
1592-8721 (Electronic)
ISSN-L
0390-6078
Issued date
16/07/2020
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
Human immunodeficiency virus (HIV) infection is associated with an increased risk of non-Hodgkin lymphoma (NHL). Even in the era of suppressive antiretroviral treatment, HIV-infected individuals remain at higher risk of developing NHL compared to the general population. To identify potential genetic risk loci, we performed case-control genome-wide association studies and a meta-analysis across three cohorts of HIV+ patients of European ancestry, including a total of 278 cases and 1924 matched controls. We observed a significant association with NHL susceptibility in the C-X-C motif chemokine ligand 12 (CXCL12) region on chromosome 10. A fine mapping analysis identified rs7919208 as the most likely causal variant (P = 4.77e-11), with the G>A polymorphism creating a new transcription factor binding site for BATF and JUND. These results suggest a modulatory role of CXCL12 regulation in the increased susceptibility to NHL observed in the HIV-infected population.
Keywords
Aggressive Non-Hodgkin's Lymphoma, Genetics, HIV, Infectious Disorders
Pubmed
Open Access
Yes
Create date
25/02/2020 17:34
Last modification date
14/09/2020 5:26
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