Wernicke-Kleist-Leonhard phenotypes of endogenous psychoses: a review of their validity .

Details

Serval ID
serval:BIB_B6DE53D0B10D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Wernicke-Kleist-Leonhard phenotypes of endogenous psychoses: a review of their validity .
Journal
Dialogues in clinical neuroscience
Author(s)
Foucher J.R., Gawlik M., Roth J.N., de Crespin de Billy C., Jeanjean L.C., Obrecht A., Mainberger O., Clauss JME, Elowe J., Weibel S., Schorr B., Cetkovich M., Morra C., Rebok F., Ban T.A., Bollmann B., Roser M.M., Hanke M.S., Jabs B.E., Franzek E.J., Berna F., Pfuhlmann B.
ISSN
1958-5969 (Electronic)
ISSN-L
1294-8322
Publication state
Published
Issued date
03/2020
Peer-reviewed
Oui
Volume
22
Number
1
Pages
37-49
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
While the ICD-DSM paradigm has been a major advance in clinical psychiatry, its usefulness for biological psychiatry is debated. By defining consensus-based disorders rather than empirically driven phenotypes, consensus classifications were not an implementation of the biomedical paradigm. In the field of endogenous psychoses, the Wernicke-Kleist-Leonhard (WKL) pathway has optimized the descriptions of 35 major phenotypes using common medical heuristics on lifelong diachronic observations. Regarding their construct validity, WKL phenotypes have good reliability and predictive and face validity. WKL phenotypes come with remarkable evidence for differential validity on age of onset, familiality, pregnancy complications, precipitating factors, and treatment response. Most impressive is the replicated separation of high- and low-familiality phenotypes. Created in the purest tradition of the biomedical paradigm, the WKL phenotypes deserve to be contrasted as credible alternatives with other approaches currently under discussion. .
Keywords
endogenous psychosis, Kleist, Leonhard, Wernicke, affect laden paraphrenia, bipolar, cataphasia, catatonia, classification, cycloid psychoses, deep phenotyping, epistemology, hebephrenia, periodic catatonia, phenotype, schizophrenia, supersensitivity psychosis, system schizophrenia, unipolar
Pubmed
Web of science
Open Access
Yes
Create date
13/01/2021 20:39
Last modification date
14/01/2021 6:26
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