Stress exposure and psychological stress responses are related to glucose concentrations during pregnancy.

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State: Public
Version: Author's accepted manuscript
Serval ID
serval:BIB_B6D31FE91F92
Type
Article: article from journal or magazin.
Collection
Publications
Title
Stress exposure and psychological stress responses are related to glucose concentrations during pregnancy.
Journal
British journal of health psychology
Author(s)
Horsch A., Kang J.S., Vial Y., Ehlert U., Borghini A., Marques-Vidal P., Jacobs I., Puder J.J.
ISSN
2044-8287 (Electronic)
ISSN-L
1359-107X
Publication state
Published
Issued date
09/2016
Peer-reviewed
Oui
Volume
21
Number
3
Pages
712-729
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
The role of stress in the development of gestational diabetes mellitus (GDM) has so far been neglected. We investigated the impact of stress exposure (pregnancy-related and pregnancy-unrelated major life events), psychological stress responses (perceived stress, subjective experience of stress, anxiety, depression, sleep), and physiological stress responses (salivary cortisol, plasma copeptin levels) on glucose concentrations during pregnancy.
Cross-sectional study, including 203 pregnant women at the maternity department of a Swiss university hospital.
All women underwent routine screening for GDM with a 75-g oral glucose-tolerance test at 24-30 weeks of gestation. Pregnancy-related and pregnancy-unrelated major life events, perceived stress, general psychological distress, anxiety, depression, and amount of sleep were assessed by validated self-report questionnaires. Cortisol was measured using fasting and bedtime saliva samples, and copeptin using fasting plasma. All data were collected before communication of the screening test results.
Significant positive associations were found between the number of pregnancy-related major life events and fasting glucose, while there was no association with pregnancy-unrelated major life events. More anxiety and depressive symptoms, a higher general level of distress, and a shorter duration of sleep were related to fasting glucose, although the latter two were no longer significant when age and BMI were controlled for. However, physiological stress responses were not associated with glucose concentrations. When testing for unique associations with fasting glucose, more general distress and shorter duration of sleep independently accounted for higher fasting glucose levels. Finally, when comparing women with and without GDM, we found that women who subsequently received the diagnosis of GDM reported more pregnancy-related life events.
Some indicators of stress exposure and psychological stress responses were associated with fasting glucose concentrations in pregnant women, thus representing important risk factors for GDM development. Statement of contribution What is already known on this subject? Only approximately half of women with gestational diabetes mellitus (GDM) report any known risk factors. Women after GDM diagnosis reported more major life events compared to healthy pregnant controls. What does this study add? Stress exposure and psychological stress responses were associated with fasting glucose concentrations in pregnant before women were aware of their GDM diagnosis. These represent important risk factors for GDM development and potential targets for intervention.

Keywords
Adult, Blood Glucose/analysis, Cross-Sectional Studies, Diabetes, Gestational/diagnosis, Diabetes, Gestational/metabolism, Diabetes, Gestational/psychology, Female, Glucose Tolerance Test, Glycopeptides/blood, Humans, Hydrocortisone/metabolism, Pregnancy, Risk Factors, Stress, Psychological/complications, Stress, Psychological/metabolism, Stress, Psychological/psychology, Switzerland, anxiety, copeptin, cortisol, depression, gestational diabetes mellitus, glucose, life events, pregnancy, stress
Pubmed
Web of science
Open Access
Yes
Create date
31/05/2016 17:55
Last modification date
20/08/2019 16:25
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