Genetic insights into the causal relationship between physical activity and cognitive functioning.
Details
Serval ID
serval:BIB_B62C93946BC8
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Genetic insights into the causal relationship between physical activity and cognitive functioning.
Journal
Scientific reports
ISSN
2045-2322 (Electronic)
ISSN-L
2045-2322
Publication state
Published
Issued date
31/03/2023
Peer-reviewed
Oui
Volume
13
Number
1
Pages
5310
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Abstract
Physical activity and cognitive functioning are strongly intertwined. However, the causal relationships underlying this association are still unclear. Physical activity can enhance brain functions, but healthy cognition may also promote engagement in physical activity. Here, we assessed the bidirectional relationships between physical activity and general cognitive functioning using Latent Heritable Confounder Mendelian Randomization (LHC-MR). Association data were drawn from two large-scale genome-wide association studies (UK Biobank and COGENT) on accelerometer-measured moderate, vigorous, and average physical activity (N = 91,084) and cognitive functioning (N = 257,841). After Bonferroni correction, we observed significant LHC-MR associations suggesting that increased fraction of both moderate (b = 0.32, CI <sub>95%</sub> = [0.17,0.47], P = 2.89e - 05) and vigorous physical activity (b = 0.22, CI <sub>95%</sub> = [0.06,0.37], P = 0.007) lead to increased cognitive functioning. In contrast, we found no evidence of a causal effect of average physical activity on cognitive functioning, and no evidence of a reverse causal effect (cognitive functioning on any physical activity measures). These findings provide new evidence supporting a beneficial role of moderate and vigorous physical activity (MVPA) on cognitive functioning.
Keywords
Genome-Wide Association Study, Exercise, Cognition, Problem Solving, Causality, Mendelian Randomization Analysis, Polymorphism, Single Nucleotide
Pubmed
Open Access
Yes
Create date
11/04/2023 11:39
Last modification date
20/04/2023 7:14