Relationship between coronary endothelial function and coronary calcification in early atherosclerosis.

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Serval ID
serval:BIB_B62B2170D9CC
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Relationship between coronary endothelial function and coronary calcification in early atherosclerosis.
Journal
Atherosclerosis
Author(s)
Han Seung Hwan, Gerber Thomas C., Al Suwaidi Jassim, Eeckhout Eric, Lennon Ryan, Rubinshtein Ronen, Lerman Amir
ISSN
1879-1484[electronic], 0021-9150[linking]
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
209
Number
1
Pages
197-200
Language
english
Abstract
BACKGROUND: The relationship between coronary endothelial function and coronary calcification is not well established. METHODS: Forty-six patients 17 men [37%]; age, 47.4+/-11.4 years prospectively underwent testing for coronary endothelial function and measurement of coronary artery calcification (CAC). RESULTS: Log CAC scores were not significantly different between patients with normal (n=31) and abnormal (n=15) response of epicardial coronary artery diameter to acetylcholine (%CAD(Ach)) (median (25, 75 percentile) 1.1 (0.0, 3.7) vs. 0.3 (0.0, 2.4), P=.32) and with normal (n=28) and abnormal (n=18) response of coronary blood flow to acetylcholine (%CBF(Ach)) (0.5 (0.0, 3.6) vs. 0.5 (0.0, 3.2), P=.76). Log CAC scores did not correlate with %CAD(Ach) (r=0.08, P=.59), %CBF(Ach) (r=0.14, P=.35). CONCLUSIONS: In patients without significant coronary artery disease, coronary endothelial dysfunction showed no apparent association with coronary calcification. Our findings suggest that these 2 markers may represent separate, independent processes in the progression of coronary atherosclerosis.
Keywords
Coronary Calcification, Early Coronary Atherosclerosis, Electron Beam Computed Tomography, Endothelial Dysfunction, Computed-Tomography, Artery Calcium, Asymptomatic Adults, Quantification, Aortas, Mice
Pubmed
Web of science
Create date
25/03/2010 17:16
Last modification date
20/08/2019 15:24
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