Relationship between coronary endothelial function and coronary calcification in early atherosclerosis.
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State: Public
Version: author
Serval ID
serval:BIB_B62B2170D9CC
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Relationship between coronary endothelial function and coronary calcification in early atherosclerosis.
Journal
Atherosclerosis
ISSN
1879-1484[electronic], 0021-9150[linking]
Publication state
Published
Issued date
2010
Peer-reviewed
Oui
Volume
209
Number
1
Pages
197-200
Language
english
Abstract
BACKGROUND: The relationship between coronary endothelial function and coronary calcification is not well established. METHODS: Forty-six patients 17 men [37%]; age, 47.4+/-11.4 years prospectively underwent testing for coronary endothelial function and measurement of coronary artery calcification (CAC). RESULTS: Log CAC scores were not significantly different between patients with normal (n=31) and abnormal (n=15) response of epicardial coronary artery diameter to acetylcholine (%CAD(Ach)) (median (25, 75 percentile) 1.1 (0.0, 3.7) vs. 0.3 (0.0, 2.4), P=.32) and with normal (n=28) and abnormal (n=18) response of coronary blood flow to acetylcholine (%CBF(Ach)) (0.5 (0.0, 3.6) vs. 0.5 (0.0, 3.2), P=.76). Log CAC scores did not correlate with %CAD(Ach) (r=0.08, P=.59), %CBF(Ach) (r=0.14, P=.35). CONCLUSIONS: In patients without significant coronary artery disease, coronary endothelial dysfunction showed no apparent association with coronary calcification. Our findings suggest that these 2 markers may represent separate, independent processes in the progression of coronary atherosclerosis.
Keywords
Coronary Calcification, Early Coronary Atherosclerosis, Electron Beam Computed Tomography, Endothelial Dysfunction, Computed-Tomography, Artery Calcium, Asymptomatic Adults, Quantification, Aortas, Mice
Pubmed
Web of science
Create date
25/03/2010 18:16
Last modification date
20/08/2019 16:24