Graves Disease Causing Pancytopenia: Case Report and Literature Review.

Details

Ressource 1Download: 30083058_BIB_B620AB706DB1.pdf (453.58 [Ko])
State: Public
Version: Final published version
License: CC BY-NC 4.0
Serval ID
serval:BIB_B620AB706DB1
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Graves Disease Causing Pancytopenia: Case Report and Literature Review.
Journal
Clinical medicine insights. Case reports
Author(s)
Pincet L., Gorostidi F.
ISSN
1179-5476 (Print)
ISSN-L
1179-5476
Publication state
Published
Issued date
2018
Peer-reviewed
Oui
Volume
11
Pages
1179547618781090
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Graves disease or other causes of thyrotoxicosis are frequently associated with cytopenia. Although anemia is the most common, other cell lineage can be affected. Pancytopenia is a rare complication of thyrotoxicosis.
We report a case of a 33-year-old Chinese man who presented a nonsevere pancytopenia in the context of a newly diagnosed Graves disease. Restauration of euthyroid state led to progressive correction of pancytopenia.
Literature review shows other rare cases of pancytopenia. It is usually nonsevere with just extremely rare cases of transfusion reported. Evolution was always favorable after achievement of euthyroid state. Its mechanism remains poorly understood, especially because those patients have no vitamin or iron deficiency. The exact physiopathological process remains unclear but 2 causes seem to overlap: reduced production of hematopoietic cells from the bone marrow and increased destruction or sequestration of mature hematopoietic cells. Despite unclear mechanism, the presence of hematologic abnormalities including pancytopenia must not be considered as a contraindication to antithyroid drug therapy.
Keywords
Graves disease, antithyroid drug therapy, hyperthyroidism, pancytopenia
Pubmed
Web of science
Open Access
Yes
Create date
14/08/2018 11:49
Last modification date
20/08/2019 15:24
Usage data