The human microbiota is associated with cardiometabolic risk across the epidemiologic transition.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_B5EAB9ED1F0A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The human microbiota is associated with cardiometabolic risk across the epidemiologic transition.
Journal
PloS one
Author(s)
Fei N., Bernabé B.P., Lie L., Baghdan D., Bedu-Addo K., Plange-Rhule J., Forrester T.E., Lambert E.V., Bovet P., Gottel N., Riesen W., Korte W., Luke A., Kliethermes S.A., Layden B.T., Gilbert J.A., Dugas L.R.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Publication state
Published
Issued date
2019
Peer-reviewed
Oui
Volume
14
Number
7
Pages
e0215262
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
Publication Status: epublish
Abstract
Oral and fecal microbial biomarkers have previously been associated with cardiometabolic (CM) risk, however, no comprehensive attempt has been made to explore this association in minority populations or across different geographic regions. We characterized gut- and oral-associated microbiota and CM risk in 655 participants of African-origin, aged 25-45, from Ghana, South Africa, Jamaica, and the United States (US). CM risk was classified using the CM risk cut-points for elevated waist circumference, elevated blood pressure and elevated fasted blood glucose, low high-density lipoprotein (HDL), and elevated triglycerides. Gut-associated bacterial alpha diversity negatively correlated with elevated blood pressure and elevated fasted blood glucose. Similarly, gut bacterial beta diversity was also significantly differentiated by waist circumference, blood pressure, triglyceridemia and HDL-cholesterolemia. Notably, differences in inter- and intra-personal gut microbial diversity were geographic-region specific. Participants meeting the cut-points for 3 out of the 5 CM risk factors were significantly more enriched with Lachnospiraceae, and were significantly depleted of Clostridiaceae, Peptostreptococcaceae, and Prevotella. The predicted relative proportions of the genes involved in the pathways for lipopolysaccharides (LPS) and butyrate synthesis were also significantly differentiated by the CM risk phenotype, whereby genes involved in the butyrate synthesis via lysine, glutarate and 4-aminobutyrate/succinate pathways and LPS synthesis pathway were enriched in participants with greater CM risk. Furthermore, inter-individual oral microbiota diversity was also significantly associated with the CM risk factors, and oral-associated Streptococcus, Prevotella, and Veillonella were enriched in participants with 3 out of the 5 CM risk factors. We demonstrate that in a diverse cohort of African-origin adults, CM risk is significantly associated with reduced microbial diversity, and the enrichment of specific bacterial taxa and predicted functional traits in both gut and oral environments. As well as providing new insights into the associations between the gut and oral microbiota and CM risk, this study also highlights the potential for novel therapeutic discoveries which target the oral and gut microbiota in CM risk.
Keywords
Adult, Cardiovascular Diseases/epidemiology, Cardiovascular Diseases/microbiology, Female, Gastrointestinal Microbiome, Ghana/epidemiology, Humans, Jamaica/epidemiology, Male, Metabolic Diseases/epidemiology, Metabolic Diseases/microbiology, Middle Aged, Mouth/microbiology, Risk Factors, South Africa/epidemiology, United States/epidemiology, Waist Circumference
Pubmed
Web of science
Open Access
Yes
Create date
30/07/2019 13:00
Last modification date
21/02/2020 6:19
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