Age differences in biological monitoring of chemical exposure: a tentative description using a toxicokinetic model

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Serval ID
serval:BIB_B5E195941CB4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Age differences in biological monitoring of chemical exposure: a tentative description using a toxicokinetic model
Journal
International Archives of Occupational and Environmental Health
Author(s)
Tomicic Catherine, Droz Pierre-Olivier
ISSN
0340-0131
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
82
Number
5
Pages
669-676
Language
english
Notes
SAPHIRID:78475
Abstract
AIM: Specific factors responsible for interindividual variability should be identified and their contribution quantified to improve the usefulness of biological monitoring. Among others, age is an easily identifiable determinant, which could play an important impact on biological variability. MATERIALS AND METHODS: A compartmental toxicokinetic model developed in previous studies for a series of metallic and organic compounds was applied to the description of age differences. Young male physiological and metabolic parameters, based on Reference Man information, were taken from preceding studies and were modified to take into account age based on available information about age differences. RESULTS: Numerical simulation using the kinetic model with the modified parameters indicates in some cases important differences due to age. The expected changes are mostly of the order of 10-20%, but differences up to 50% were observed in some cases. CONCLUSION: These differences appear to depend on the chemical and on the biological entity considered. Further work should be done to improve our estimates of these parameters, by considering for example uncertainty and variability in these parameters. [Authors]
Keywords
Environmental Monitoring , Age Factors , Occupational Exposure
Pubmed
Web of science
Open Access
Yes
Create date
19/01/2010 17:30
Last modification date
01/10/2019 6:19
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