Blocking the B7-H4 pathway with novel recombinant antibodies enhances T cell-mediated antitumor responses.

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Serval ID
serval:BIB_B5DDB69A0181
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Blocking the B7-H4 pathway with novel recombinant antibodies enhances T cell-mediated antitumor responses.
Journal
Oncoimmunology
Author(s)
Dangaj D., Scholler N.
ISSN
2162-4011 (Print)
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
2
Number
8
Pages
e25913
Language
english
Notes
Publication types: JOURNAL ARTICLE Publication Status: ppublish
Abstract
B7-H4 inhibits T-cell activation and is widely expressed by solid neoplasms. We have recently demonstrated that the expression of B7-H4 on the surface of malignant cells in vivo is inducible, and that novel anti-B7-H4 recombinant antibodies can reverse the inhibition of tumor-specific T cells. Thus, antibodies targeting the B7-H4 pathways may extend the survival of cancer patients by restoring T cell-mediated antitumor responses.
Pubmed
Web of science
Create date
07/03/2014 18:08
Last modification date
20/08/2019 15:24
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