Expression of bcl-6 and CD10 in primary mediastinal large B-cell lymphoma: evidence for derivation from germinal center B cells?

Details

Serval ID
serval:BIB_B5C286E960B1
Type
Article: article from journal or magazin.
Collection
Publications
Title
Expression of bcl-6 and CD10 in primary mediastinal large B-cell lymphoma: evidence for derivation from germinal center B cells?
Journal
American Journal of Surgical Pathology
Author(s)
de Leval L., Ferry J.A., Falini B., Shipp M., Harris N.L.
ISSN
0147-5185[print], 0147-5185[linking]
Publication state
Published
Issued date
2001
Volume
25
Number
10
Pages
1277-1282
Language
english
Abstract
Primary mediastinal large B-cell lymphomas (LBCLs) constitute a unique subtype of diffuse LBCLs, with distinct clinical, immunophenotypic, and morphologic features. These lymphomas are thought to originate from the thymus, and it has been hypothesized that they derive from a population of B lymphocytes normally present in the thymic medulla. Most diffuse LBCLs harbor somatic mutations in their immunoglobulin genes, suggesting that they have been exposed to the germinal center. To investigate the possible relationship of mediastinal LBCLs to germinal center B cells, we analyzed the expression of bcl-6 and CD10 in 19 mediastinal LBCLs, using an immunoperoxidase technique on formalin-fixed tissue. We found that 19 of 19 (100%) mediastinal LBCLs were bcl-6+ and 6 of 19 (32%) mediastinal LBCLs were CD10+. Because mediastinal LBCLs usually lack BCL-6 gene rearrangement or mutations, expression of bcl-6 and CD10 in these tumors tends to support a germinal center derivation.
Keywords
Adolescent, Adult, Aged, Cell Count, DNA-Binding Proteins/metabolism, Female, Follow-Up Studies, Humans, Immunoenzyme Techniques, Lymphoma, B-Cell/metabolism, Lymphoma, B-Cell/pathology, Lymphoma, Large B-Cell, Diffuse/metabolism, Lymphoma, Large B-Cell, Diffuse/pathology, Male, Mediastinal Neoplasms/metabolism, Mediastinal Neoplasms/pathology, Middle Aged, Neoplasm Proteins/metabolism, Neoplasm Staging, Neprilysin/metabolism, Proto-Oncogene Proteins/metabolism, Proto-Oncogene Proteins c-bcl-6, Thymus Gland/metabolism, Thymus Gland/pathology, Transcription Factors/metabolism, Tumor Markers, Biological/metabolism
Pubmed
Create date
28/10/2010 10:37
Last modification date
20/08/2019 15:24
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