Molecular linkage of the human alpha 1-antitrypsin and corticosteroid-binding globulin genes on chromosome 14q32.1.

Details

Serval ID
serval:BIB_B5C1AFA57551
Type
Article: article from journal or magazin.
Collection
Publications
Title
Molecular linkage of the human alpha 1-antitrypsin and corticosteroid-binding globulin genes on chromosome 14q32.1.
Journal
Mammalian Genome
Author(s)
Rollini P., Fournier R.E.
ISSN
0938-8990 (Print)
ISSN-L
0938-8990
Publication state
Published
Issued date
1997
Volume
8
Number
12
Pages
913-916
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.Publication Status: ppublish
Abstract
The genes encoding alpha 1-antitrypsin (alpha 1AT; gene symbol PI) and corticosteroid-binding globulin (CBG) are part of a cluster of structurally related serine protease inhibitor (serpin) genes on human Chromosome (Chr) 14q32.1. This cluster also includes the genes encoding alpha 1-antichymotrypsin (AACT) and protein C inhibitor (PCI), as well as an alpha 1-antitrypsin-related sequence (ATR; gene symbol PIL). In this report we present a detailed restriction map of a 110-kb region of genomic DNA that includes the alpha 1AT, ATR, and CBG genes. Gene order in this interval is tel-alpha 1AT-ATR-CBG-cen, and all three genes are transcribed in a distal-to-proximal orientation. Within the gene cluster, ATR is approximately 12 kb downstream of alpha 1AT, and CBG is about 57 kb downstream of alpha 1AT. Repetitive DNA sequences have been mapped throughout the interval, and several new restriction site polymorphisms in the region are described.
Keywords
Chromosome Mapping, Chromosomes, Human, Pair 14/genetics, Humans, Polymorphism, Restriction Fragment Length, Repetitive Sequences, Nucleic Acid, Serpins/genetics, Transcortin/genetics, alpha 1-Antitrypsin/genetics
Pubmed
Web of science
Create date
11/11/2011 11:13
Last modification date
20/08/2019 15:24
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