Cytokine regulation of chondrocyte functions.

Details

Serval ID
serval:BIB_B5BA2DA6125A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Cytokine regulation of chondrocyte functions.
Journal
Journal of Rheumatology. Supplement
Author(s)
Lotz M., Blanco F.J., von Kempis J., Dudler J., Maier R., Villiger P.M., Geng Y.
ISSN
0380-0903 (Print)
ISSN-L
0380-0903
Publication state
Published
Issued date
1995
Volume
22
Number
43
Pages
104-108
Language
english
Notes
Publication types: Journal Article ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish
Abstract
Regulation of chondrocyte secretory functions and proliferation by cytokines and growth factors is central to cartilage development and maintenance of homeostasis in the mature organism. Depending on the type of extracellular stimulus, chondrocytes can be induced to enter a catabolic matrix degrading or anabolic matrix forming functional program. Interleukin I and transforming growth factor beta are the prototypic stimuli for the catabolic and anabolic program, respectively. Insight into the regulation of chondrocytes by cytokines and growth factors provides the basis for improved concepts of osteoarthritis pathogenesis and new perspectives for therapeutic interventions.
Keywords
Cartilage/cytology, Cartilage/drug effects, Cells, Cultured, Cytokines/immunology, Cytokines/physiology, Humans, Interferon-gamma/physiology, Interleukin-1/physiology, Interleukin-6/physiology, Osteoarthritis/drug therapy, Osteoarthritis/immunology, Signal Transduction, Transforming Growth Factor beta/physiology
Pubmed
Web of science
Create date
25/01/2008 8:32
Last modification date
20/08/2019 15:24
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