Isolated limb perfusion: distinct tourniquet and tumor necrosis factor effects on the early hemodynamic response.
Details
Serval ID
serval:BIB_B58D01BB4FDB
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Isolated limb perfusion: distinct tourniquet and tumor necrosis factor effects on the early hemodynamic response.
Journal
Archives of surgery
ISSN
0004-0010
Publication state
Published
Issued date
2003
Peer-reviewed
Oui
Volume
138
Number
1
Pages
17-25
Language
english
Notes
Publication types: Comparative Study ; Journal Article - Publication Status: ppublish
Abstract
HYPOTHESIS: Recent evidence indicates that tumor response rates after isolated limb perfusion (ILP) are improved when tumor necrosis factor (TNF) is added to the locoregional perfusion of high doses of chemotherapy. Other factors, related to the patient or the ILP procedure, may interfere with the specific role of TNF in the early hemodynamic response after ILP with TNF and high-dose chemotherapy. DESIGN: Case-control study. SETTING: Tertiary care university hospital. PATIENTS: Thirty-eight patients with a locoregionally advanced tumor of a limb treated by ILP with TNF and high-dose chemotherapy (TNF group) were compared with 31 similar patients treated by ILP with high-dose chemotherapy alone (non-TNF group). INTERVENTIONS: Swan-Ganz catheter hemodynamic recordings, patients' treatment data collection, and TNF and interleukin 6 plasma level measurements at regular intervals during the first 36 hours following ILP. MAIN OUTCOME MEASURES: Hemodynamic profile and total fluid and catecholamine administration. RESULTS: In the TNF group, significant changes were observed (P<.006): the mean arterial pressure and the systemic vascular resistance index decreased, and the temperature, heart rate, and cardiac index increased. These hemodynamic alterations started when the ILP tourniquet was released (ie, when or shortly after the systemic TNF levels were the highest). The minimal mean arterial pressure, the minimal systemic vascular resistance index, the maximal cardiac index, the intensive care unit stay, and the interleukin 6 maximal systemic levels were significantly (P<.001 for all) correlated to the log(10) of the systemic TNF level. In the non-TNF group, only a brief decrease in the blood pressure following tourniquet release and an increase in the temperature and in the heart rate were statistically significant (P<.006). Despite significantly more fluid and catecholamine administration in the TNF group, the mean arterial pressure and the systemic vascular resistance index were significantly (P<.001) lower than in the non-TNF group. CONCLUSIONS: Release of the tourniquet induces a blood pressure decrease that lasts less than 1 hour in the absence of TNF and that is distinct from the septic shock-like hemodynamic profile following TNF administration. The systemic TNF levels are correlated to this hemodynamic response, which can be observed even at low TNF levels.
Keywords
Adult, Aged, Aged, 80 and over, Antineoplastic Agents, Case-Control Studies, Chemotherapy, Cancer, Regional Perfusion, Extremities, Female, Hemodynamics, Humans, Hypotension, Interleukin-6, Male, Middle Aged, Neoplasms, Retrospective Studies, Tourniquets, Tumor Necrosis Factor-alpha
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 16:52
Last modification date
31/08/2019 13:45