Mental health and its associations with glucose-lowering medication in women with gestational diabetes mellitus. A prospective clinical cohort study.

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Serval ID
serval:BIB_B5800C3F9C86
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Mental health and its associations with glucose-lowering medication in women with gestational diabetes mellitus. A prospective clinical cohort study.
Journal
Psychoneuroendocrinology
Author(s)
Gilbert L., Nikolaou A., Quansah D.Y., Rossel J.B., Horsch A., Puder J.J.
ISSN
1873-3360 (Electronic)
ISSN-L
0306-4530
Publication state
Published
Issued date
02/2021
Peer-reviewed
Oui
Volume
124
Pages
105095
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Mental health symptoms are frequent in women with gestational diabetes mellitus (GDM) and may influence glycemic control. We therefore investigated if mental health symptoms (high depression and low well-being scores) predicted a need for glucose-lowering medication and if this use of medication influenced the trajectory of mental health during pregnancy and in the postpartum period.
We included 341 pregnant women from a cohort of GDM women in a Swiss University Hospital. The World Health Organization Well-being Index-Five was collected at the first and last GDM and at the postpartum clinical visits and the Edinburgh Postnatal Depression Scale at the first GDM and the postpartum clinical visits. Medication intake was extracted from participants' medical records. We conducted linear and logistic regressions with depression as an interaction factor.
Mental health symptoms did not predict a need for medication (all p ≥ 0.29). Mental health improved over time (both p ≤ 0.001) and use of medication did not predict this change (all p ≥ 0.40). In women with symptoms of depression, medication was associated with less improvement in well-being at the postpartum clinical visit (p for interaction=0.013).
Mental health and glucose-lowering medication did not influence each other in an unfavourable way in this cohort of women with GDM.
Keywords
Depression, insulin, metformin, postpartum, pregnancy, well-being, GDM, mental health, Depression, Insulin, Metformin, Postpartum, Pregnancy, Well-being
Pubmed
Web of science
Open Access
Yes
Funding(s)
Swiss National Science Foundation / 32003B_176119
Create date
08/12/2020 18:47
Last modification date
13/03/2021 6:22
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