MRI-based assessment of the pineal gland in a large population of children aged 0-5 years and comparison with pineoblastoma: part II, the cystic gland.

Details

Serval ID
serval:BIB_B55AEA599038
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
MRI-based assessment of the pineal gland in a large population of children aged 0-5 years and comparison with pineoblastoma: part II, the cystic gland.
Journal
Neuroradiology
Author(s)
Sirin S., de Jong M.C., Galluzzi P., Maeder P., Brisse H.J., Castelijns J.A., de Graaf P., Goericke S.L.
Working group(s)
European Retinoblastoma Imaging Collaboration (ERIC)
ISSN
1432-1920 (Electronic)
ISSN-L
0028-3940
Publication state
Published
Issued date
07/2016
Peer-reviewed
Oui
Volume
58
Number
7
Pages
713-721
Language
english
Notes
Publication types: Comparative Study ; Evaluation Studies ; Journal Article ; Multicenter Study
Publication Status: ppublish
Abstract
Pineal cysts are a common incidental finding on brain MRI with resulting difficulties in differentiation between normal glands and pineal pathologies. The aim of this study was to assess the size and morphology of the cystic pineal gland in children (0-5 years) and compare the findings with published pineoblastoma cases.
In this retrospective multicenter study, 257 MR examinations (232 children, 0-5 years) were evaluated regarding pineal gland size (width, height, planimetric area, maximal cyst(s) size) and morphology. We performed linear regression analysis with 99 % prediction intervals of gland size versus age for the size parameters. Results were compared with a recent meta-analysis of pineoblastoma by de Jong et al.
Follow-up was available in 25 children showing stable cystic findings in 48 %, cyst size increase in 36 %, and decrease in 16 %. Linear regression analysis gave 99 % upper prediction bounds of 10.8 mm, 10.9 mm, 7.7 mm and 66.9 mm(2), respectively, for cyst size, width, height, and area. The slopes (size increase per month) of each parameter were 0.030, 0.046, 0.021, and 0.25, respectively. Most of the pineoblastomas showed a size larger than the 99 % upper prediction margin, but with considerable overlap between the groups.
We presented age-adapted normal values for size and morphology of the cystic pineal gland in children aged 0 to 5 years. Analysis of size is helpful in discriminating normal glands from cystic pineal pathologies such as pineoblastoma. We also presented guidelines for the approach of a solid or cystic pineal gland in hereditary retinoblastoma patients.

Keywords
Brain Neoplasms/diagnostic imaging, Central Nervous System Cysts/diagnostic imaging, Central Nervous System Cysts/pathology, Child, Preschool, Diagnosis, Differential, Europe, Female, Humans, Infant, Infant, Newborn, Magnetic Resonance Imaging/methods, Male, Pineal Gland/diagnostic imaging, Pineal Gland/pathology, Pinealoma/diagnostic imaging, Pinealoma/pathology, Reference Values, Reproducibility of Results, Retrospective Studies, Sensitivity and Specificity, Gland size, Pediatric, Pineal gland, Pineoblastoma, Retinoblastoma
Pubmed
Web of science
Open Access
Yes
Create date
17/05/2016 18:00
Last modification date
20/08/2019 15:23
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