Relief of severe pulmonary hypertension after closure of a large ventricular septal defect using low dose inhaled nitric oxide.

Details

Serval ID
serval:BIB_B5462C8F4054
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
Relief of severe pulmonary hypertension after closure of a large ventricular septal defect using low dose inhaled nitric oxide.
Journal
Intensive Care Medicine
Author(s)
Berner M., Beghetti M., Ricou B., Rouge J.C., Prêtre R., Friedli B.
ISSN
0342-4642 (Print)
ISSN-L
0342-4642
Publication state
Published
Issued date
1993
Peer-reviewed
Oui
Volume
19
Number
2
Pages
75-77
Language
english
Notes
Publication types: Publication Status: ppublish
Abstract
A 16-month-old girl developed severe pulmonary hypertension after closure of a large ventricular septal defect. All conventional therapeutic measures failed; an attempt to add nitric oxide at a continuous low dose to the inspired gas allowed resolution of pulmonary hypertension and low cardiac output. This report documents that continuous inhalation of low dose nitric oxide is capable of selective resolution of pulmonary hypertension following cardiac surgery for a large septal defect in a child. This suggests that a transient dysfunction in the release of nitric oxide by the pulmonary endothelial cell is responsible for the vasoconstriction.
Pubmed
Web of science
Create date
16/12/2014 18:19
Last modification date
20/08/2019 16:23
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