Superantigens and retroviral infection: insights from mouse mammary tumor virus.
Details
Serval ID
serval:BIB_B54116E7972E
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Superantigens and retroviral infection: insights from mouse mammary tumor virus.
Journal
Immunology Today
ISSN
0167-5699 (Print)
ISSN-L
0167-5699
Publication state
Published
Issued date
1994
Peer-reviewed
Oui
Volume
15
Number
4
Pages
184-190
Language
english
Abstract
Superantigens induce a vigorous immune response by stimulating T cells that express particular T-cell receptor V beta chains. Mouse mammary tumor virus is a milk-transmitted retrovirus that encodes such a superantigen. Paradoxically, as discussed by Werner Held and colleagues, the strong superantigen-induced immune response permits the survival of the virus via T-cell dependent clonal expansion of infected B cells.
Keywords
Animals, Antigens, Viral/immunology, B-Lymphocytes/physiology, Lymphoma/immunology, Mammary Tumor Virus, Mouse/immunology, Mice, Retroviridae Infections/immunology, Superantigens/immunology, T-Lymphocytes/physiology, Tumor Virus Infections/immunology
Pubmed
Web of science
Create date
17/01/2008 16:24
Last modification date
20/08/2019 16:23