Radioimmunotherapy combined with maintenance anti-CD20 antibody may trigger long-term protective T cell immunity in follicular lymphoma patients.

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State: Public
Version: Final published version
Serval ID
serval:BIB_B534D097DE8D
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Radioimmunotherapy combined with maintenance anti-CD20 antibody may trigger long-term protective T cell immunity in follicular lymphoma patients.
Journal
Clinical and Developmental Immunology
Author(s)
Buchegger F., Larson S.M., Mach J.P., Chalandon Y., Dietrich P.Y., Cairoli A., Prior J.O., Romero P., Speiser D.E.
ISSN
1740-2530 (Electronic)
ISSN-L
1740-2522
Publication state
Published
Issued date
2013
Volume
2013
Pages
875343
Language
english
Abstract
Growing evidence suggests that the patient's immune response may play a major role in the long-term efficacy of antibody therapies of follicular lymphoma (FL). Particular long-lasting recurrence free survivals have been observed after first line, single agent rituximab or after radioimmunotherapy (RIT). Rituximab maintenance, furthermore, has a major efficacy in prolonging recurrence free survival after chemotherapy. On the other hand, RIT as a single step treatment showed a remarkable capacity to induce complete and partial remissions when applied in recurrence and as initial treatment of FL or given for consolidation. These clinical results strongly suggest that RIT combined with rituximab maintenance could stabilize the high percentages of patients with CR and PR induced by RIT. While the precise mechanisms of the long-term efficacy of these 2 treatments are not elucidated, different observations suggest that the patient's T cell immune response could be decisive. With this review, we discuss the potential role of the patient's immune system under rituximab and RIT and argue that the T cell immunity might be particularly promoted when combining the 2 antibody treatments in the early therapy of FL.
Pubmed
Web of science
Open Access
Yes
Create date
06/01/2014 10:58
Last modification date
20/08/2019 16:23
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