Evaluating bone marrow metastasis of neuroblastoma with iodine-123-MIBG scintigraphy and MRI.

Details

Serval ID
serval:BIB_B52B8891C50A
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Evaluating bone marrow metastasis of neuroblastoma with iodine-123-MIBG scintigraphy and MRI.
Journal
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Author(s)
Lebtahi N., Gudinchet F., Nenadov-Beck M., Beck D., Bischof Delaloye A.
ISSN
0161-5505
Publication state
Published
Issued date
1997
Peer-reviewed
Oui
Volume
38
Number
9
Pages
1389-92
Language
english
Notes
Publication types: Case Reports ; Journal Article - Publication Status: ppublish
Abstract
Of 10 patients with neuroblastoma who had both 123I-MIBG scintigraphy and MRI at diagnosis, four presented with bone marrow metastasis that was diagnosed by both imaging modalities and confirmed by bone marrow biopsy and smears. This report focuses on the follow up of the four patients with bone marrow metastasis. MIBG scintigraphy and MRI were concordant in two patients, a case of normalization and a case of relapse in the seventh dorsal vertebra confirmed by surgical biopsy. The last two patients presented a normalized MIBG scan for marrow infiltration after chemotherapy but persistent abnormal MRI signal of several vertebrae, suggesting marrow infiltration, up to 27 mo after the end of chemotherapy in one case. In the second patient, MRI bone marrow aspect returned to normal 4 mo after the end of chemotherapy. Bone marrow biopsy remained negative in these two MIBG-negative patients. These cases suggest that in presence of complete normalization of the MIBG scan after chemotherapy, the persistence of a hypointense signal on bone marrow on T1WI does not necessarily indicate persistence of disease but may be due to delayed normalization. Therefore, attention must be paid to the delay of signal normalization on MRI (which can be as long as more than 2 yr after the end of chemotherapy) in order to avoid false-positive interpretation.
Keywords
3-Iodobenzylguanidine, Bone Marrow Neoplasms, Child, Child, Preschool, Humans, Iodine Radioisotopes, Iodobenzenes, Magnetic Resonance Imaging, Male, Neuroblastoma
Pubmed
Web of science
Create date
20/03/2008 9:34
Last modification date
20/08/2019 15:23
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