Synthetic T<sub>2</sub>-weighted images of the lumbar spine derived from an accelerated T<sub>2</sub> mapping sequence: Comparison to conventional T<sub>2</sub>w turbo spin echo.

Details

Serval ID
serval:BIB_B526CCC5FA46
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Synthetic T<sub>2</sub>-weighted images of the lumbar spine derived from an accelerated T<sub>2</sub> mapping sequence: Comparison to conventional T<sub>2</sub>w turbo spin echo.
Journal
Magnetic resonance imaging
Author(s)
Raudner M., Toth D.F., Schreiner M.M., Hilbert T., Kober T., Juras V., Windhager R., Trattnig S.
ISSN
1873-5894 (Electronic)
ISSN-L
0730-725X
Publication state
Published
Issued date
12/2021
Peer-reviewed
Oui
Volume
84
Pages
92-100
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
To evaluate the diagnostic usefulness of synthetic T <sub>2</sub> -weighted images of the lumbar spine derived from ten-fold undersampled k-space data using GRAPPATINI, a combination of a model-based approach for rapid T <sub>2</sub> and M <sub>0</sub> quantification (MARTINI) extended by generalized autocalibrating partial parallel acquistion (GRAPPA).
Overall, 58 individuals (26 female, mean age 23.3 ± 8.1 years) were examined at 3 Tesla with sagittal and axial T <sub>2</sub> w turbo spin echo (TSE) sequences compared to synthetic T <sub>2</sub> <sub>-</sub> weighted contrasts derived at identical effective echo times and spatial resolutions. Two blinded readers graded disk degeneration and evaluated the lumbar intervertebral disks for present herniation or annular tear. One reader reassessed all studies after four weeks. Weighted kappa statistics were calculated to assess inter-rater and intra-rater agreement. Also, all studies were segmented manually by one reader to compute contrast ratios (CR) and contrast-to-noise ratios (CNR) of the nucleus pulposus and the annulus fibrosus.
Overall, the CR <sub>T2w</sub> was 4.45 ± 1.80 and CR <sub>T2synth</sub> was 4.71 ± 2.14. Both correlated (rsp = 0.768;p < 0.001) and differed (0.26 ± 1.38;p = 0.002) significantly. The CNR <sub>T2w</sub> was 1.73 ± 0.52 and CNR <sub>T2synth</sub> was 1.63 ± 0.50. Both correlated (rsp = 0.875;p < 0.001) and differed (-0.10 ± 0.25;p < 0.001) significantly. The inter-rater agreement was substantial to almost perfect (κ = 0.808-0.925) with the intra-rater agreement also substantial to almost perfect (κ = 0.862-0.963). The area under the curve of the receiver operating characteristics assessing disk herniation or annular tear ranged from 0.787 to 0.892.
This study concludes that synthetic images derived by GRAPPATINI can be used for clinical routine assessment with inter-rater and intra-rater agreements comparable to conventional T <sub>2</sub> w TSE.
Keywords
Adolescent, Adult, Female, Humans, Intervertebral Disc/diagnostic imaging, Intervertebral Disc Degeneration/diagnostic imaging, Intervertebral Disc Displacement/diagnostic imaging, Lumbar Vertebrae/diagnostic imaging, Magnetic Resonance Imaging/methods, Young Adult, Intervertebral disc, Intervertebral disc degeneration, Intervertebral disc discplacement, Spine
Pubmed
Web of science
Create date
04/10/2021 10:39
Last modification date
10/02/2024 7:14
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