Animal models of psoriasis and psoriatic arthritis: an update.

Details

Serval ID
serval:BIB_B51329D79055
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Animal models of psoriasis and psoriatic arthritis: an update.
Journal
Current Rheumatology Reports
Author(s)
Conrad C., Nestle F.O.
ISSN
1523-3774 (Print)
ISSN-L
1523-3774
Publication state
Published
Issued date
2006
Volume
8
Number
5
Pages
342-347
Language
english
Notes
Publication types: Journal Article ; Review
Abstract
Psoriasis is a chronic inflammatory skin disorder characterized by accelerated growth and altered differentiation of keratinocytes and angiogenesis with marked ectasia of blood vessels. It develops through interactions between the skin and immune system mediated by T cells, dendritic cells, and inflammatory cytokines. The understanding of the cellular and molecular alterations underlying the disease has advanced, yet the majority of factors leading to the initiation and maintenance of disease remain elusive. Researchers have attempted to reproduce psoriasis in genetically modified and xenotransplantation mouse models to gain insight into its pathogenesis, and they are beginning to use these models to test new therapeutic agents and define mechanisms of action. Every mouse model has strengths and weaknesses, with room for improvement. Still, these models will accelerate knowledge of psoriasis pathogenesis and aid in the development of new therapeutics.
Keywords
Animals, Arthritis, Psoriatic/blood, Arthritis, Psoriatic/immunology, Biological Markers/blood, Cytokines/blood, Disease Models, Animal, Immunity, Cellular, Keratinocytes/pathology, Psoriasis/blood, Psoriasis/immunology, T-Lymphocytes/immunology
Pubmed
Create date
26/03/2012 10:33
Last modification date
20/08/2019 15:23
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