Biosafety assessment of probiotics used for human consumption: recommendations from the EU-PROSAFE project

Details

Serval ID
serval:BIB_B51301615A0E
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Biosafety assessment of probiotics used for human consumption: recommendations from the EU-PROSAFE project
Journal
Trends in Food Science and Technology
Author(s)
Vankerckhoven V., Huys G., Vancanneyt M., Vael C., Klare I., Romond M.B., Entenza J.M., Moreillon P., Wind R.D., Knol J., Wiertz E., Pot B., Vaughan E.E., Kahlmeter G., Goossens H.
ISSN
0924-2244
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
19
Number
2
Pages
102-114
Language
english
Abstract
On June 26-27, 2006, 60 academic and industry scientists gathered during the PROSAFE workshop to discuss recommendations on taxonomy, antibiotic resistance, in vitro assessment of virulence and in vivo assessment of safety of probiotics used for human consumption. For identification of lactic acid bacteria (LAB) intended for probiotic use, it was recommended that conventional biochemical methods should be complemented with molecular methods and that these should be performed by an expert lab. Using the newly developed LAB Susceptibility test Medium (LSM), tentative epidemiological cut-off values were proposed. It was recommended that potentially probiotic strains not belonging to the wildtype distributions of relevant antimicrobials should not be developed as future products for human or animal consumption. Furthermore, it was recommended that the use of strains harbouring known and confirmed virulence genes should be avoided. Finally, for in vivo assessment of safety by investigating strain pathogenicity in animal models, the rat endocarditis model appeared to be the most reliable model tested in the PROSAFE project. Moreover, consensus was reached for approving the necessity of a human colonisation study in a randomised placebo-controlled double-blind design; however, further discussions are needed on the details of such as study.
Web of science
Create date
20/03/2009 13:42
Last modification date
20/08/2019 15:23
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