Alcohol drinking, the metabolic syndrome and diabetes in a population with high mean alcohol consumption.

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State: Public
Version: author
Serval ID
serval:BIB_B5079276064E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Alcohol drinking, the metabolic syndrome and diabetes in a population with high mean alcohol consumption.
Journal
Diabetic medicine
Author(s)
Clerc O., Nanchen D., Cornuz J., Marques-Vidal P., Gmel G., Daeppen J.B., Paccaud F., Mooser V., Waeber G., Vollenweider P., Rodondi N.
ISSN
1464-5491 (Electronic)
ISSN-L
0742-3071
Publication state
Published
Issued date
11/2010
Peer-reviewed
Oui
Volume
27
Number
11
Pages
1241-1249
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
To investigate the relationship of alcohol consumption with the metabolic syndrome and diabetes in a population-based study with high mean alcohol consumption. Few data exist on these conditions in high-risk drinkers.
In 6172 adults aged 35-75 years, alcohol consumption was categorized as 0, 1-6, 7-13, 14-20, 21-27, 28-34 and ≥ 35 drinks/week or as non-drinkers (0), low-risk (1-13), medium-to-high-risk (14-34) and very-high-risk (≥ 35) drinkers. Alcohol consumption was objectively confirmed by biochemical tests. In multivariate analysis, we assessed the relationship of alcohol consumption with adjusted prevalence of the metabolic syndrome, diabetes and insulin resistance, determined with the homeostasis model assessment of insulin resistance (HOMA-IR).
Seventy-three per cent of participants consumed alcohol, 16% were medium-to-high-risk drinkers and 2% very-high-risk drinkers. In multivariate analysis, the prevalence of the metabolic syndrome, diabetes and mean HOMA-IR decreased with low-risk drinking and increased with high-risk drinking. Adjusted prevalence of the metabolic syndrome was 24% in non-drinkers, 19% in low-risk (P<0.001 vs. non-drinkers), 20% in medium-to-high-risk and 29% in very-high-risk drinkers (P=0.005 vs. low-risk). Adjusted prevalence of diabetes was 6.0% in non-drinkers, 3.6% in low-risk (P<0.001 vs. non-drinkers), 3.8% in medium-to-high-risk and 6.7% in very-high-risk drinkers (P=0.046 vs. low-risk). Adjusted HOMA-IR was 2.47 in non-drinkers, 2.14 in low-risk (P<0.001 vs. non-drinkers), 2.27 in medium-to-high-risk and 2.53 in very-high-risk drinkers (P=0.04 vs. low-risk). These relationships did not differ according to beverage types.
Alcohol has a U-shaped relationship with the metabolic syndrome, diabetes and HOMA-IR, without differences between beverage types.

Keywords
Adult, Aged, Alcohol Drinking/adverse effects, Alcohol Drinking/epidemiology, Cardiovascular Diseases/epidemiology, Cardiovascular Diseases/prevention & control, Cross-Sectional Studies, Diabetes Mellitus/epidemiology, Diabetic Angiopathies/epidemiology, Diabetic Angiopathies/prevention & control, Female, Humans, Insulin Resistance/physiology, Male, Metabolic Syndrome X/complications, Metabolic Syndrome X/epidemiology, Middle Aged, Prevalence, Risk Factors, Switzerland/epidemiology
Pubmed
Web of science
Create date
27/10/2010 10:43
Last modification date
20/08/2019 15:23
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