No variation of physical performance and perceived exertion after adrenal gland stimulation by synthetic ACTH (Synacthen) in cyclists.

Details

Ressource 1Download: serval:BIB_B4FD11D28F30.P001 (565.60 [Ko])
State: Public
Version: author
License: Not specified
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_B4FD11D28F30
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
No variation of physical performance and perceived exertion after adrenal gland stimulation by synthetic ACTH (Synacthen) in cyclists.
Journal
European Journal of Applied Physiology
Author(s)
Baume N., Steel G., Edwards T., Thorstensen E., Miller B.F.
ISSN
1439-6319
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
104
Number
4
Pages
589-600
Language
english
Abstract
There is anecdotal evidence that athletes use the banned substance Synacthen because of its perceived benefit with its associated rise in cortisol. To test the performance-enhancing effects of Synacthen, eight trained cyclists completed two, 2-day exercise sessions separated by 7-10 days. On the first day of each 2-day exercise session, subjects received either Synacthen (0.25 mg, TX) or placebo (PLA) injection. Performance was assessed by a 20-km time trial (TT) after a 90-min fatigue period on day 1 and without the fatiguing protocol on day 2. Plasma androgens and ACTH concentrations were measured during the exercise bouts as well as the rate of perceived exertion (RPE). Spot urines were analyzed for androgens and glucocorticoids quantification. Basal plasma hormones did not differ significantly between PLA and TX groups before and 24 h after the IM injection (P > 0.05). After TX injection, ACTH peaked at 30 min and hormone profiles were significantly different compared to the PLA trial (P < 0.001). RPE increased significantly in both groups as the exercise sessions progressed (P < 0.001) but was not influenced by treatment. The time to completion of the TT was not affected on both days by Synacthen treatment. In the present study, a single IM injection of synthetic ACTH did not improve either acute or subsequent cycling performance and did not influence perceived exertion. The investigated urinary hormones did not vary after treatment, reinforcing the difficulty for ACTH abuse detection.
Keywords
Adrenal Glands, Adrenocorticotropic Hormone, Adult, Athletic Performance, Bicycling, Cross-Over Studies, Dehydroepiandrosterone, Double-Blind Method, Glucocorticoids, Glucuronides, Heart Rate, Humans, Hydrocortisone, Male, Physical Exertion, Testosterone
Pubmed
Web of science
Open Access
Yes
Create date
29/01/2009 22:14
Last modification date
01/10/2019 6:19
Usage data