Management of allergy transfer upon solid organ transplantation.

Details

Serval ID
serval:BIB_B4CCBADEDA6A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Management of allergy transfer upon solid organ transplantation.
Journal
American journal of transplantation
Author(s)
Muller Y.D., Vionnet J., Beyeler F., Eigenmann P., Caubet J.C., Villard J., Berney T., Scherer K., Spertini F., Fricker M.P., Lang C., Schmid-Grendelmeier P., Benden C., Roux Lombard P., Aubert V., Immer F., Pascual M. (co-last), Harr T.
Working group(s)
Swiss Transplant Cohort Study
Contributor(s)
Amico P., Aubert J.D., Banz V., Beldi G., Benden C., Berger C., Binet I., Bochud P.Y., Branca S., Bucher H., Carell T., Catana E., Chalandon Y., de Geest S., de Rougemont O., Dickenmann M., Duchosal M., Elkrief L., Fehr T., Ferrari-Lacraz S., Garzoni C., Gasche Soccal P., Gaudet C., Giostra E., Golshayan D., Hadaya K., Halter J., Hauri D., Heim D., Hess C., Hillinger S., Hirsch H.H., Hofbauer G., Huynh-Do U., Immer F., Klaghofer R., Koller M., Laesser B., Laube G., Lehmann R., Lovis C., Majno P., Manuel O., Marti H.P., Yves Martin P., Martinelli M., Meylan P., Morel P., Mueller N.J., Müller A., Müller T., Müllhaupt B., Pascual M., Passweg J., Posfay-Barbe K., Rick J., Roosnek E., Rosselet A., Rothlin S., Ruschitzka F., Schanz U., Schaub S., Schnyder A., Seiler C., Sprachta J., Stampf S., Steiger J., Stirnimann G., Toso C., Van Delden C., Venetz J.P., Villard J., Wick M., Wilhelm M., Yerly P.
ISSN
1600-6143 (Electronic)
ISSN-L
1600-6135
Publication state
Published
Issued date
03/2020
Peer-reviewed
Oui
Volume
20
Number
3
Pages
834-843
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Allergy transfer upon solid organ transplantation has been reported in the literature, although only few data are available as to the frequency, significance, and management of these cases. Based on a review of 577 consecutive deceased donors from the Swisstransplant Donor-Registry, 3 cases (0.5%) of fatal anaphylaxis were identified, 2 because of peanut and 1 of wasp allergy. The sera of all 3 donors and their 10 paired recipients, prospectively collected before and after transplantation for the Swiss Transplant Cohort Study, were retrospectively processed using a commercial protein microarray fluorescent test. As early as 5 days posttransplantation, newly acquired peanut-specific IgE were transiently detected from 1 donor to 3 recipients, of whom 1 liver and lung recipients developed grade III anaphylaxis. Yet, to define how allergy testing should be performed in transplant recipients and to better understand the impact of immunosuppressive therapy on IgE sensitization, we prospectively studied 5 atopic living-donor kidney recipients. All pollen-specific IgE and >90% of skin prick tests remained positive 7 days and 3 months after transplantation, indicating that early diagnosis of donor-derived IgE sensitization is possible. Importantly, we propose recommendations with respect to safety for recipients undergoing solid-organ transplantation from donors with a history of fatal anaphylaxis.
Keywords
IgE, Immunoglobulin E, allergy transfer, anaphylaxis, immunosuppression, management, solid organ transplantation, allergy, business/management, clinical decision-making, clinical research/practice, diagnostic techniques and imaging, guidelines, immunoglobulin E, immunosuppression/immune modulation, organ transplantation in general, patient safety
Pubmed
Web of science
Open Access
Yes
Create date
25/09/2019 7:32
Last modification date
21/08/2020 5:21
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