Human immunoglobulins and Fc fragments promote microtubule assembly via tau proteins and induce conformational changes of neuronal microtubules in vitro.

Details

Serval ID
serval:BIB_B4AB998834F3
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Human immunoglobulins and Fc fragments promote microtubule assembly via tau proteins and induce conformational changes of neuronal microtubules in vitro.
Journal
Neuroreport
Author(s)
Riederer I.M., Pfulg C., Bouras C., Giannakopoulos P., Riederer B.M.
ISSN
0959-4965
Publication state
Published
Issued date
2003
Peer-reviewed
Oui
Volume
14
Number
1
Pages
117-21
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Abstract
The influence of human immunoglobulins (Ig) in neuronal cytoskeleton stability was studied in vitro. Here we show that human Ig and Fc fragments stimulate animal and human microtubule assembly by binding to microtubules via tau isoforms. In presence of Ig, microtubules show increased aggregation, twisting and rigidity. Non-immune Ig and Fc fragments promote microtubule assembly in temperature-dependent manner and stabilize microtubules at a molecular ratio of 1 Ig per 4 tubulin dimers. These in vitro data provide an experimental support for an immuno-mediated modulation of the cytoskeleton. In conjunction with previous neuropathological data, they suggest that Ig could participate in early stages of neurodegeneration by affecting the microtubule stability in vivo.
Keywords
Aged, Aged, 80 and over, Animals, Cattle, Cerebral Cortex, Cytoskeletal Proteins, Cytoskeleton, Dimerization, Female, Humans, Immunoglobulin Fc Fragments, Immunoglobulins, Male, Microscopy, Electron, Microtubules, Morphogenesis, Nerve Degeneration, Protein Conformation, Swine, tau Proteins
Pubmed
Web of science
Create date
24/01/2008 14:34
Last modification date
20/08/2019 15:23
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