In vitro cytokine profiles as indicators of relapse activity and clinical course in multiple sclerosis

Details

Serval ID
serval:BIB_B4917F2A9F04
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
In vitro cytokine profiles as indicators of relapse activity and clinical course in multiple sclerosis
Journal
Multiple Sclerosis
Author(s)
Schluep  M., van Melle  G., Henry  H., Stadler  C., Roth-Wicky  B., Magistretti  P. J.
ISSN
1352-4585 (Print)
Publication state
Published
Issued date
06/1998
Volume
4
Number
3
Pages
198-202
Notes
Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jun
Abstract
In vitro production of tumor necrosis factor-alpha (TNF-alpha), interleukin-2 (IL-2), IL-4, IL-6, IL-10 and oligoclonal IgG (IgG OB) was evaluated in the aim to investigate their profile in correlation with multiple sclerosis (MS) clinical activity and clinical course. Whole blood stimulation with lipopolysaccharide or concanavalin A was performed in 61 patients presenting with relapsing-remitting, relapsing-progressive or chronic progressive MS; treatments received were: none, azathioprine (AZA), cyclosporin, cyclophosphamide, subcutaneous interferon-beta 1a (IFN-beta 1a) and corticosteroids (CST). The cinetics of cytokine production showed that (i) in the absence of treatment, TNF-alpha and IL-6 dropped respectively after and during the periods surrounding relapse, while IL-4 was increasing before and IL-10 after relapse; (ii) with AZA, TNF-alpha and IL-6 lowered before exacerbation, IL-4 prolonged high levels after and IL-10 before relapse; (iii) with IFN-beta 1a, IL-10 was already increasing before relapse, and TNF-alpha was higher after relapse. When cytokine levels were analysed independently from MS clinical activity, the use of AZA inhibited IgG OB and TNF-alpha synthesis (P = 0.002) but increased IL-4 (P = 0.0024), whereas IFN-beta 1a stimulated TNF-alpha and inhibited IgG OB and IL-4 production. CST inhibited TNF-alpha, IL-6, IL-4 and IgG OB synthesis. This study stresses both the weight of clinical parameters and of methodology used in results obtained in cytokine analysis in MS.
Keywords
Biological Markers/blood Disease Progression Humans Interleukins/*blood Multiple Sclerosis/blood/*drug therapy Recurrence Remission Induction Tumor Necrosis Factor-alpha/*metabolism
Pubmed
Web of science
Create date
25/01/2008 12:46
Last modification date
20/08/2019 15:23
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