Peripheral inflammation induces up-regulation of TRPV2 expression in rat DRG

Details

Serval ID
serval:BIB_B48115DE18F6
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Peripheral inflammation induces up-regulation of TRPV2 expression in rat DRG
Journal
Pain
Author(s)
Shimosato  G., Amaya  F., Ueda  M., Tanaka  Y., Decosterd  I., Tanaka  M.
ISSN
0304-3959 (Print)
Publication state
Published
Issued date
12/2005
Volume
119
Number
1-3
Pages
225-32
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Dec 15
Abstract
The transient receptor potential vanilloid subfamily member 2 (TRPV2) is a cation channel activated by temperatures above 52 degrees C. To analyze the contribution of TRPV2 to the development of inflammation-induced hyperalgesia, the expression of TRPV2 in primary sensory neurons was analyzed after intraplantar injection of complete Freund's adjuvant (CFA). Using specific antibodies, an increase in TRPV2-expressing neurons was identified after inflammation. TRPV2 expression is concentrated in a subset of medium-sized dorsal root ganglion neurons, independent of transient receptor potential vanilloid subfamily member 1 (TRPV1) expression. A similar distribution of TRPV2 was observed after inflammation. Intraplantar injection of nerve growth factor increased TRPV1 expression but not TRPV2, suggesting that induction of TRPV2 expression is driven by a mechanism distinct from that for TRPV1. Heat hyperalgesia assessment after chemical desensitization of TRPV1 by resiniferatoxin demonstrates a possible role for TRPV2 in inflammation at high temperatures (>56 degrees C). These results suggest that TRPV2 upregulation contributes to peripheral sensitization during inflammation and is responsible for pain hypersensitivity to noxious high temperature stimuli.
Keywords
Animals *Behavior, Animal Freund's Adjuvant Ganglia, Spinal/drug effects/*metabolism Hyperalgesia/etiology/*metabolism Inflammation/chemically induced/complications/*metabolism Male Neuralgia/etiology/*metabolism Neurons/drug effects/*metabolism Rats Rats, Sprague-Dawley TRPV Cation Channels/*metabolism Up-Regulation/drug effects
Pubmed
Web of science
Create date
28/01/2008 10:45
Last modification date
20/08/2019 15:22
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