Altered interhemispheric connectivity in individuals with Tourette's disorder.

Details

Serval ID
serval:BIB_B44D5BEA4FF1
Type
Article: article from journal or magazin.
Collection
Publications
Title
Altered interhemispheric connectivity in individuals with Tourette's disorder.
Journal
The American journal of psychiatry
Author(s)
Plessen K.J., Wentzel-Larsen T., Hugdahl K., Feineigle P., Klein J., Staib L.H., Leckman J.F., Bansal R., Peterson B.S.
ISSN
0002-953X (Print)
ISSN-L
0002-953X
Publication state
Published
Issued date
11/2004
Peer-reviewed
Oui
Volume
161
Number
11
Pages
2028-2037
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish
Abstract
The corpus callosum is the major commissure connecting the cerebral hemispheres. Prior evidence suggests involvement of the corpus callosum in the pathophysiology of Tourette's disorder. The authors assessed corpus callosum size and anatomical connectivity across the cerebral hemispheres in persons with Tourette's disorder.
The size of the corpus callosum was determined on the true midsagittal slices of reformatted, high-resolution magnetic resonance imaging scans and compared across groups in a cross-sectional case-control study of 158 subjects with Tourette's disorder and 121 healthy comparison subjects, ages 5-65 years.
In the context of increasing midsagittal corpus callosum area from childhood to age 30 years, children with Tourette's disorder had smaller overall corpus callosum size, whereas adults with Tourette's disorder on average had larger corpus callosum size, yielding a prominent interaction of diagnosis with age. Corpus callosum size correlated positively with tic severity. Corpus callosum size also correlated inversely with dorsolateral prefrontal and orbitofrontal cortical volumes in both the subjects with Tourette's disorder and the comparison subjects, but the magnitudes of the correlations were significantly greater in the group with Tourette's disorder. The effects of medication and comorbid illnesses had no appreciable influence on the findings.
Given prior evidence for the role of prefrontal hypertrophy in the regulation of tic symptoms, the current findings suggest that neural plasticity may contribute to smaller corpus callosum size in persons with Tourette's disorder, which thereby limits neuronal trafficking across the cerebral hemispheres and reduces input to cortical inhibitory interneurons within the prefrontal cortices. Reduced inhibitory input may in turn enhance prefrontal excitation, thus helping to control tics and possibly contributing to the cortical hyperexcitatibility reported previously in patients with Tourette's disorder.
Keywords
Adolescent, Adult, Age Factors, Attention Deficit Disorder with Hyperactivity/epidemiology, Case-Control Studies, Cerebral Cortex/anatomy & histology, Comorbidity, Corpus Callosum/anatomy & histology, Corpus Callosum/physiopathology, Cross-Sectional Studies, Functional Laterality/physiology, Humans, Magnetic Resonance Imaging, Male, Neuronal Plasticity/physiology, Obsessive-Compulsive Disorder/epidemiology, Prefrontal Cortex/physiopathology, Severity of Illness Index, Tourette Syndrome/diagnosis, Tourette Syndrome/epidemiology, Tourette Syndrome/physiopathology
Pubmed
Web of science
Create date
21/02/2019 10:03
Last modification date
20/08/2019 15:22
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