Histology of portal vascular changes associated with idiopathic non-cirrhotic portal hypertension: nomenclature and definition.

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State: Public
Version: Author's accepted manuscript
Serval ID
serval:BIB_B4472D8F90DD
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Histology of portal vascular changes associated with idiopathic non-cirrhotic portal hypertension: nomenclature and definition.
Journal
Histopathology
Author(s)
Guido M., Alves VAF, Balabaud C., Bathal P.S., Bioulac-Sage P., Colombari R., Crawford J.M., Dhillon A.P., Ferrell L.D., Gill R.M., Hytiroglou P., Nakanuma Y., Paradis V., Quaglia A., Rautou P.E., Theise N.D., Thung S., Tsui WMS, Sempoux C., Snover D., van Leeuwen D.J.
Working group(s)
International Liver Pathology Study Group
ISSN
1365-2559 (Electronic)
ISSN-L
0309-0167
Publication state
Published
Issued date
01/2019
Peer-reviewed
Oui
Volume
74
Number
2
Pages
219-226
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Idiopathic non-cirrhotic portal hypertension (INCPH) is a rare vascular liver disease that has attracted new interest in recent years. It is characterised by clinical signs of portal hypertension in the absence of cirrhosis or severe fibrosis and any known cause of portal hypertension. As much uncertainty exists about INCPH pathophysiology, and no definite diagnostic tests are available, liver biopsy is an essential tool for achieving a definite diagnosis. Unfortunately, the histological diagnosis of INCPH is not always straightforward, as the characteristic lesions are unevenly distributed, vary greatly in their severity, are often very subtle, and are not all necessarily present in a single case. Furthermore, specifically for the characteristic portal vessel changes observed in INCPH, the terminology and definition are ambiguous, which adds complexity to the already complex clinicopathological scenario. An international study group of liver pathologists and hepatologists pursued a consensus on nomenclature for the portal vascular lesions of INCPH. Such standardisation may assist pathologists in the recognition of such lesions, and will possibly facilitate further advancement in this field.
Keywords
Humans, Hypertension, Portal/pathology, Liver/pathology, idiopathic non-cirrhotic portal hypertension, liver vascular lesions, obliterative portal venopathy, phlebosclerosis
Pubmed
Web of science
Create date
28/08/2018 7:34
Last modification date
20/08/2019 15:22
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