Plasminogen activator inhibitor type 1 gene polymorphisms and haplotypes are associated with plasma plasminogen activator inhibitor type 1 levels but not with myocardial infarction or stroke

Details

Serval ID
serval:BIB_B440A5C07D61
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Plasminogen activator inhibitor type 1 gene polymorphisms and haplotypes are associated with plasma plasminogen activator inhibitor type 1 levels but not with myocardial infarction or stroke
Journal
American Heart Journal
Author(s)
Ding  J., Nicklas  B. J., Fallin  M. D., de Rekeneire  N., Kritchevsky  S. B., Pahor  M., Rodondi  N., Li  R., Zmuda  J. M., Harris  T. B.
ISSN
1097-6744 (Electronic)
Publication state
Published
Issued date
12/2006
Peer-reviewed
Oui
Volume
152
Number
6
Pages
1109-15
Notes
Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't --- Old month value: Dec
Abstract
BACKGROUND: The 4G allele in the promoter region of the plasminogen activator inhibitor type 1 (PAI-1) gene is associated with higher plasma PAI-1 levels and activity, but its association with cardiovascular diseases is unclear. We investigated the association of polymorphisms and common haplotypes of the PAI-1 gene with plasma PAI-1 levels, as well as the risk of myocardial infarction and stroke. METHODS AND RESULTS: This study is a prospective analysis of 2995 community-based participants (41% blacks and 51% women) aged 70 to 79 years old in the Health, Aging, and Body Composition Study. From 1997/1998 to 2001, 177 myocardial infarction events and 101 stroke events were identified. In addition to the 4G/5G polymorphism, 2 potential functional variants and other 4 haplotype-tagging variants were genotyped. In general linear models, the 4G allele was associated with higher PAI-1 levels after adjusting for age, sex, race, and site (26, 29, and 32 ng/mL for 5G/5G, 4G/5G, and 4G/4G, respectively; P for trend < .0001), but none of the other 6 polymorphisms was associated with PAI-1 levels. Haplotype analysis produced similar results. However, in Cox proportional hazard models, neither the polymorphisms nor the common haplotypes of the PAI-1 gene was associated with the risk of either myocardial infarction or stroke. CONCLUSIONS: The 4G allele is associated with higher PAI-1 levels, but this study does not support an association of the PAI gene polymorphisms with the risk of either myocardial infarction or stroke.
Keywords
Aged Alleles Cerebrovascular Accident/*genetics Female *Genetic Predisposition to Disease *Haplotypes Humans Linear Models Male Myocardial Infarction/*genetics Plasminogen Activator Inhibitor 1/*blood/*genetics *Polymorphism, Genetic Promoter Regions (Genetics) Proportional Hazards Models Prospective Studies
Pubmed
Web of science
Create date
28/01/2008 12:01
Last modification date
20/08/2019 15:22
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