Immunobiology of IL-26.

Details

Serval ID
serval:BIB_B42FC1E8E78A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Immunobiology of IL-26.
Journal
The Journal of investigative dermatology
Author(s)
Gilliet M., Modlin R.L.
ISSN
1523-1747 (Electronic)
ISSN-L
0022-202X
Publication state
In Press
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: aheadofprint
Abstract
T helper 17 (Th17) cells produce a set of cytokines that include IL-17 family members, IL-21, IL-22, and IL-26. These cytokines all contribute to the classic function of Th17 cells in combatting extracellular infection and promoting inflammation in autoimmune diseases. However, of the Th17 cytokines, only IL-26 has direct antimicrobial activity against microbes and can activate a broad range of immune cells through its ability to bind DNA and trigger pattern recognition receptors. It is noteworthy that IL-26 is produced by mammalian cells, including human Th17 cells, but is absent in rodents. As such, IL-26 is a potential therapeutic target to augment host immune responses against microbial pathogens but also to prevent inflammation and tissue damage in a variety of autoimmune diseases.
Keywords
Antimicrobial, Autoimmunity, IL-26, Skin inflammation, Th17
Pubmed
Create date
16/01/2024 16:41
Last modification date
17/01/2024 7:13
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