Different expression of chromogranin A and chromogranin B in various types of pituitary adenomas.

Details

Serval ID
serval:BIB_B4274F5E1AD5
Type
Article: article from journal or magazin.
Collection
Publications
Title
Different expression of chromogranin A and chromogranin B in various types of pituitary adenomas.
Journal
Zentralblatt Für Pathologie
Author(s)
Riva C., Leutner M., Capella C., Usellini L., la Rosa S., Brianza M.R., Buffa R.
ISSN
0863-4106 (Print)
ISSN-L
0863-4106
Publication state
Published
Issued date
1993
Peer-reviewed
Oui
Volume
139
Number
2
Pages
165-170
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Two hundred and nineteen (33 GH, 21 GH-PRL, 38 PRL, 16 ACTH, 1 TSH cell functioning and 38 FSH-LH, 17 alpha-chain, 8 mixed, 27 minimal glycoprotein--MIN-GLYC--, 11 small argyrophil granule--SAG--, 4 silent TSH-sTSH--and 5 silent ACTH-sACTH--cell nonfunctioning) adenomas were investigated immunohistochemically with antibodies against ACTH, GH, PRL, TSH, FSH, LH alpha-hCG, chromogranin A (CgA) and chromogranin B (CgB). For immunostaining of CgB a novel monoclonal (B 11) antibody was employed. All types of adenomas were positive for CgB. CgA was widely expressed in nonfunctioning FSH-LH, MIN-GLYC, SAG, MIXED, alpha-chain adenomas and in the single TSH cell functioning adenoma. CgA was lacking both in PRL and ACTH functioning adenomas and was poorly expressed in GH and GH-PRL functioning adenomas. The distribution of Grimelius' silver paralleled that of CgA-IR, but not that of CgB-IR. We conclude that: 1) CgB may be considered as an universal granular marker for pituitary adenomas, 2) CgA is an important marker for nonfunctioning adenomas, 3) the pattern of distribution of CgA and CgB for most nonfunctioning ("null cell" according to Kovacs et al.) adenomas favors their origin from glycoprotein producing (FSH/LH, TSH) cells.
Keywords
Adenoma/pathology, Adrenocorticotropic Hormone/analysis, Antibodies, Monoclonal, Biomarkers, Tumor/analysis, Chromogranin A, Chromogranin B, Chromogranins/analysis, Growth Hormone/analysis, Humans, Immunohistochemistry, Pituitary Neoplasms/pathology, Prolactin/analysis, Thyrotropin/analysis
Pubmed
Create date
07/09/2016 8:46
Last modification date
20/08/2019 15:22
Usage data