MicroRNA epigenetic alterations in human cancer: one step forward in diagnosis and treatment.

Details

Serval ID
serval:BIB_B402901BCB85
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
MicroRNA epigenetic alterations in human cancer: one step forward in diagnosis and treatment.
Journal
International Journal of Cancer. Journal International du Cancer
Author(s)
Yang N., Coukos G., Zhang L.
ISSN
1097-0215 (Electronic)
ISSN-L
0020-7136
Publication state
Published
Issued date
2008
Volume
122
Number
5
Pages
963-968
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; ReviewPublication Status: ppublish
Abstract
MicroRNAs (miRNAs) are approximately 22 nt non-coding RNAs, which regulate gene expression in a sequence-specific manner via translational inhibition or messenger RNA (mRNA) degradation. Since the discovery of their fundamental mechanisms of action, the field of miRNAs has opened a new era in the understanding of small noncoding RNAs. By molecular cloning and bioinformatic approaches, miRNAs have been identified in viruses, plants and animals. miRNAs are predicted to negatively target up to one-third of human mRNAs. Cancer is a complex genetic disease caused by abnormalities in gene structure and expression. Previous studies have heavily focused on protein-coding genes; however, accumulating evidence is revealing an important role of miRNAs in cancer. Epigenetics is defined as mitotically and/or meiotically heritable changes in gene expression that are not accompanied by changes in DNA sequence. Given the critical roles of miRNAs and epigenetics in cancer, characterizing the epigenetic regulation of miRNAs will provide novel opportunities for the development of cancer biomarkers and/or the identification of new therapeutic targets in the foreseeable future.
Keywords
Epigenesis, Genetic, Gene Expression Regulation, Neoplastic, Humans, MicroRNAs, Neoplasms/diagnosis, Neoplasms/genetics
Pubmed
Web of science
Create date
14/10/2014 11:42
Last modification date
20/08/2019 15:22
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