Predictors of endocarditis in isolates from cultures of blood following dental extractions in rats with periodontal disease.

Details

Ressource 1Download: serval:BIB_B3F727D30BAC.P001 (568.65 [Ko])
State: Public
Version: author
License: Not specified
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_B3F727D30BAC
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Predictors of endocarditis in isolates from cultures of blood following dental extractions in rats with periodontal disease.
Journal
Journal of Infectious Diseases
Author(s)
Moreillon P., Overholser C.D., Malinverni R., Bille J., Glauser M.P.
ISSN
0022-1899 (Print)
ISSN-L
0022-1899
Publication state
Published
Issued date
1988
Volume
157
Number
5
Pages
990-995
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Rats with periodontitis and catheter-induced aortic valve vegetations underwent dental extractions. Cultures of blood obtained 1 min later showed polymicrobial bacteremia in 19 of 19 rats, mostly due to viridans streptococci (18 of 19), Morganella (15 of 19), group G streptococci (13 of 19), and Staphylococcus aureus (10 of 19). Viridans streptococci circulated in higher numbers than did group G streptococci and S. aureus (P less than .01). Three days after dental extractions, 18 of 20 rats had endocarditis. Fifteen (83%) of 18 infections were due to group G streptococci, 9 (50%) of 18 were due to S. aureus, and 2 (11%) of 18 were due to viridans streptococci (P less than .05). In vitro, adherence to platelet-fibrin matrices of endocarditis strain 8 of group G streptococcus was two times greater than that of endocarditis strain S. aureus 23 and three to four times greater than that of Streptococcus sanguis 44 and Morganella morganii 93 (P less than 10(-5)). The inoculum size that produced endocarditis in 90% of rats after iv challenge was 10(5) cfu for group G streptococcus strain 8 and 10(7) for S. sanguis 44.
Keywords
Animals, Bacterial Adhesion, Blood/microbiology, Endocarditis, Bacterial/etiology, Endocarditis, Bacterial/microbiology, Female, Gram-Negative Bacteria/isolation & purification, Periodontal Diseases/complications, Rats, Rats, Inbred Strains, Staphylococcal Infections/microbiology, Staphylococcus aureus/isolation & purification, Streptococcal Infections/microbiology, Streptococcus/isolation & purification, Tooth Extraction/adverse effects
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 14:57
Last modification date
01/10/2019 7:19
Usage data