Evaluation of adhesions after laparoscopic myomectomy using the Harmonic Ace and the auto-crosslinked hyaluronan gel vs Ringer's lactate solution.

Details

Serval ID
serval:BIB_B3E648266234
Type
Article: article from journal or magazin.
Collection
Publications
Title
Evaluation of adhesions after laparoscopic myomectomy using the Harmonic Ace and the auto-crosslinked hyaluronan gel vs Ringer's lactate solution.
Journal
Clinical and experimental obstetrics & gynecology
Author(s)
Litta P., Pluchino N., Freschi L., Borgato S., Angioni S.
ISSN
0390-6663 (Print)
ISSN-L
0390-6663
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
40
Number
2
Pages
210-214
Language
english
Notes
Publication types: Comparative Study ; Journal Article
Publication Status: ppublish
Abstract
To evaluate the efficacy of a crosslinked hyaluronic acid (HA) for the prevention of postsurgical adhesions after laparoscopic myomectomy using the Harmonic Ace.
Women 23-42 years of age who wished to conceive underwent laparoscopic myomectomy. As adhesion preventing agents, crosslinked HA gel was applied on the myometrial scar at the end of the surgery in Group A, whereas in Group B a Ringer's lactate solution was used in a prospective, observational study. Second-look mini-laparoscopy was performed 45-60 days after surgery and the adhesions were assessed according to a site-specific modified scoring.
The incidence of postoperative adhesions was the same in both groups, but anatomically significant adhesions and site-specific modified score was significantly reduced in Group A compared to Group B control group (31.8% vs 54.6% and 1.05 +/- 1 vs 2.27 +/- 2.5, respectively).
The use of auto-cross-linked HA gel confirms a protection on adhesion formation on myometrial wounds, although the degree of this effect appears to be weak. The absence of adnexa adhesions using the HA and a different uterine incision appear remarkable, although a larger number of patients is required to confirm the present findings.
Keywords
Adult, Cross-Linking Reagents, Female, Gels, Humans, Hyaluronic Acid/administration & dosage, Isotonic Solutions, Laparoscopy/adverse effects, Laparoscopy/instrumentation, Laparoscopy/methods, Postoperative Complications, Prospective Studies, Ringer's Lactate, Second-Look Surgery, Tissue Adhesions/epidemiology, Tissue Adhesions/prevention & control, Ultrasonic Surgical Procedures/adverse effects, Ultrasonic Surgical Procedures/methods, Uterine Myomectomy/adverse effects
Pubmed
Web of science
Create date
15/09/2023 12:24
Last modification date
27/09/2023 8:57
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