Vitamin D and cognitive function: A Mendelian randomisation study.

Details

Serval ID
serval:BIB_B3DD05034F89
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Vitamin D and cognitive function: A Mendelian randomisation study.
Journal
Scientific reports
Author(s)
Maddock J., Zhou A., Cavadino A., Kuźma E., Bao Y., Smart M.C., Saum K.U., Schöttker B., Engmann J., Kjærgaard M., Karhunen V., Zhan Y., Lehtimäki T., Rovio S.P., Byberg L., Lahti J., Marques-Vidal P., Sen A., Perna L., Schirmer H., Singh-Manoux A., Auvinen J., Hutri-Kähönen N., Kähönen M., Kilander L., Räikkönen K., Melhus H., Ingelsson E., Guessous I., Petrovic K.E., Schmidt H., Schmidt R., Vollenweider P., Lind L., Eriksson J.G., Michaëlsson K., Raitakari O.T., Hägg S., Pedersen N.L., Herzig K.H., Järvelin M.R., Veijola J., Kivimaki M., Jorde R., Brenner H., Kumari M., Power C., Llewellyn D.J., Hyppönen E.
ISSN
2045-2322 (Electronic)
ISSN-L
2045-2322
Publication state
Published
Issued date
16/10/2017
Peer-reviewed
Oui
Volume
7
Number
1
Pages
13230
Language
english
Notes
Publication types: Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
The causal nature of the association between hypovitaminosis D and poor cognitive function in mid- to later-life is uncertain. Using a Mendelian randomisation(MR) approach, we examined the causal relationship between 25(OH)D and cognitive function. Data came from 172,349 participants from 17 cohorts. DHCR7(rs12785878), CYP2R1 rs12794714) and their combined synthesis score were chosen to proxy 25(OH)D. Cognitive tests were standardised into global and memory scores. Analyses were stratified by 25(OH)D tertiles, sex and age. Random effects meta-analyses assessed associations between 25(OH)D and cognitive function. Associations of serum 25(OH)D with global and memory-related cognitive function were non-linear (lower cognitive scores for both low and high 25(OH)D, p <sub>curvature</sub> ≤ 0.006), with much of the curvature attributed to a single study. DHCR7, CYP2R1, and the synthesis score were associated with small reductions in 25(OH)D per vitamin D-decreasing allele. However, coefficients for associations with global or memory-related cognitive function were non-significant and in opposing directions for DHCR7 and CYP2R1, with no overall association observed for the synthesis score. Coefficients for the synthesis score and global and memory cognition were similar when stratified by 25(OH)D tertiles, sex and age. We found no evidence for serum 25(OH)D concentration as a causal factor for cognitive performance in mid- to later life.
Keywords
Aged, Cognition/physiology, Cohort Studies, Female, Humans, Male, Mendelian Randomization Analysis, Middle Aged, Phenotype, Polymorphism, Single Nucleotide, Vitamin D/analogs & derivatives, Vitamin D/blood, Vitamin D/physiology, Vitamins/physiology
Pubmed
Web of science
Open Access
Yes
Create date
26/10/2017 8:45
Last modification date
22/07/2020 5:26
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